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Estrogen-progestins and progestins for the management of endometriosis
Endometriosis is characterized by frequent recurrences of symptoms and lesions even after extirpative surgery. Because medical therapies control but do not cure the disease, long periods of pharmacologic management may be needed until pregnancy desire or, sometimes, physiologic menopause.
P. Vercellini+5 more
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Estrogens, progestins, and headache
PIP: Migraine headaches appear to be linked to the menstrual cycle and the use of oral contraceptives (OCs). Migraine attacks occur during menses in 60% of women and appear to be related to the withdrawal of estrogen. The fluctuations in estrogen levels associated with migraine headaches produce biochemical changes in prostaglandin production ...
Stephen D. Silberstein+1 more
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Classification and pharmacology of progestins
Maturitas, 2003Besides the natural progestin, progesterone, there are different classes of progestins, such as retroprogesterone (i.e. dydrogesterone), progesterone derivatives (i.e. medrogestone) 17alpha-hydroxyprogesterone derivatives (i.e. chlormadinone acetate, cyproterone acetate, medroxyprogesterone acetate, megestrol acetate), 19-norprogesterone derivatives (i.
Johannes C. Huber+6 more
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Pharmacological profile of progestins
Maturitas, 2004The synthetic progestins used so far for contraception and menopausal hormone therapy are derived either from testosterone (19-nortestosterone derivatives) or from progesterone (17-OH progesterone derivatives and 19-norprogesterone derivatives). Among the 19-nortestosterone derivatives, the estrane group include norethisterone (NET) and its metabolites,
R. Sitruk-Ware
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Progestins of today and tomorrow
Current Opinion in Obstetrics and Gynecology, 2022Purpose of review To review the current literature on the multiple types and uses of progestins in reproductive healthcare. Recent findings Progestins for contraceptive use are available in multiple forms, with the ongoing development of transdermal ...
Serena Liu+3 more
semanticscholar +1 more source
Human Reproduction Update, 2020
BACKGROUND Progestins are capable of suppressing endogenous LH secretion from the pituitary. Progestins can be used orally and are less expensive than GnRH analogues. However, early endometrial exposure to progestin precludes a fresh embryo transfer (ET),
B. Ata+4 more
semanticscholar +1 more source
BACKGROUND Progestins are capable of suppressing endogenous LH secretion from the pituitary. Progestins can be used orally and are less expensive than GnRH analogues. However, early endometrial exposure to progestin precludes a fresh embryo transfer (ET),
B. Ata+4 more
semanticscholar +1 more source
Human and zebrafish nuclear progesterone receptors are differently activated by manifold progestins.
Environmental Science and Technology, 2020Environmental risk of natural and synthetic ligands of the nuclear progesterone receptor (nPR) has been pointed out, however there is still a lack of mechanistic information regarding their ability to interact with nuclear PR in aquatic species.
Clémentine Garoche+7 more
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Progestins and carcinogenesis [PDF]
Progesterone and its analogs may exert opposite effects on cell proliferation, apoptosis, and epithelial-mesenchymal transition, leading to higher cell motility and metastasis. Their ultimate effect is determined by a number of factors: the structure and concentration of the steroid, its affinity for various forms of steroid hormone receptors ...
I. A. Morozov, T. A. Shchelkunova
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