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Clinical pharmacology of progestins
Minerva Obstetrics and Gynecology, 2022In this paper, we report general pharmacological profile and major biological activities of natural progesterone (P) and progestins. The aim of this article consists of synthesizing the principal aspects of pharmacology and metabolism of P and progestins related to the clinical consequences of their use.We review scientific literature on the topic ...
Capozzi, Anna +2 more
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Progesterone, progestins and the breast in menopause treatment
Climacteric, 2018Breast cancer is the main risk associated with menopause hormone therapy (MHT). It is a hormone-dependent cancer. In postmenopausal women, about 80% of cases are estradiol receptor-positive.
A. Gompel, G. Plu-Bureau
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The challenge presented by progestins in ecotoxicological research: a critical review.
Environmental Science and Technology, 2015Around 20 progestins (also called gestagens, progestogens, or progestagens) are used today in assisting a range of medical conditions from endometrial cancer to uterine bleeding and as an important component of oral contraception.
Vimal Kumar +8 more
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Maturitas, 1996
The history of progesterone and hormone replacement therapy goes back to 1934 when Butenandt obtained crystalline progesterone and Kaufmann started to treat ovariectomized women with both estrogens and progesterone (Table 1). Today synthetic perorally active 19-nortestosterone and 17-alpha-hydroxyprogesterone derivatives are used in addition to ...
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The history of progesterone and hormone replacement therapy goes back to 1934 when Butenandt obtained crystalline progesterone and Kaufmann started to treat ovariectomized women with both estrogens and progesterone (Table 1). Today synthetic perorally active 19-nortestosterone and 17-alpha-hydroxyprogesterone derivatives are used in addition to ...
openaire +2 more sources
Drospirenone: a novel progestin
Expert Opinion on Pharmacotherapy, 2007Drospirenone is a novel progestin available in combined oral contraceptives and menopausal hormonal therapy. Similar to its parent compound spirolactone, an analog of spironolactone, drospirenone has antimineralocorticoid and antiandrogenic activity.
Sharon A Winer, Andrea J. Rapkin
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Environmental Science and Technology, 2015
Progestins alter hormone homeostasis and may result in reproductive effects in humans and animals. Thus far, studies in fish have focused on the hypothalamic-pituitary-gonadal (HPG)-axis and reproduction, but other effects have little been investigated ...
Yanbin Zhao, S. Castiglioni, K. Fent
semanticscholar +1 more source
Progestins alter hormone homeostasis and may result in reproductive effects in humans and animals. Thus far, studies in fish have focused on the hypothalamic-pituitary-gonadal (HPG)-axis and reproduction, but other effects have little been investigated ...
Yanbin Zhao, S. Castiglioni, K. Fent
semanticscholar +1 more source
Contraception, 2001
There is considerable confusion concerning the use of the term "progestin" in referring to progestational compounds. Such term is often restricted to progestational agents that are synthetic and excludes progesterone which is a natural compound. In 1930 when progesterone had not yet been isolated the term "progestin" was proposed for the name of this
Frank Z. Stanczyk, Milan R. Henzl
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There is considerable confusion concerning the use of the term "progestin" in referring to progestational compounds. Such term is often restricted to progestational agents that are synthetic and excludes progesterone which is a natural compound. In 1930 when progesterone had not yet been isolated the term "progestin" was proposed for the name of this
Frank Z. Stanczyk, Milan R. Henzl
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The androgenicity of progestins
The American Journal of Medicine, 1995All steroid hormones are structurally similar, but relatively minor differences cause profound alterations in biochemical activity. The 21-carbon series (pregnane nucleus) includes the corticoids and the true progestins (e.g., medroxyprogesterone acetate).
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On the mechanism of action of progestins
Acta Endocrinologica, 1981Abstract. The effect of two synthetic injectable progestins, norethisterone oenanthate3 (NET-e) and medroxyprogesterone acetate (MPA) upon the hypothalamic pituitary unit was evaluated in post-menopausal women (PMW) and in castrated individuals with androgen un-responsiveness in order to gain insight into their mechanism of gonadotrophin inhibition ...
Martha Medina +4 more
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Several synthetic progestins with different potencies adversely affect reproduction of fish.
Environmental Science and Technology, 2013Synthetic progestins are widely used as a component in both contraceptives and in hormone replacement therapy (HRT), both on their own and in combination with EE2.
T. Runnalls +4 more
semanticscholar +1 more source