Results 191 to 200 of about 2,728,807 (361)

The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

, 2020
Kaitlyn H. Smith, Amit Budhraja, J.A. Lynch, Kathryn G. Roberts, John C. Panetta, Jon P. Connelly, Meghan E. Turnis, Shondra M. Pruett‐Miller, John D. Schuetz, Charles G. Mullighan, Joseph T. Opferman   +10 more
openalex   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Comparative study of the conservative and surgical treatment of spontaneous cerebellar hemorrhage. [PDF]

Front Neurol
Yang C, Huang L, Xu P, Zhang Z, Che W, Ren S, Wu G, Wang L.   +7 more
europepmc   +1 more source

Occupational Prognosis [PDF]

Journal of Epidemiology & Community Health, 1964
R D, WEIR, W, BRASS
openaire   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Impact of intracranial pressure and related parameters on prognosis in patients undergoing surgery for ruptured intracranial aneurysms. [PDF]

Neurosurg Rev
Wang T, Xiao Y, Liao Q, Wang F, Jiang Y, Cui S, Chen P, Huo Y, Shu J, Fan W, Li C, Deng X, Li P, Lu Z, Duan Y, Liang R.   +15 more
europepmc   +1 more source

Recognition of DNA Methylation Molecular Features for Diagnosis and Prognosis in Gastric Cancer

, 2021
Donghui Liu, Long Li, Liru Wang, Chao Wang, Xiaowei Hu, Qingxin Jiang, Xuyao Wang, Guiqin Xue, Yu Liu, Dongbo Xue   +9 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer [PDF]

, 2019
Beili Zhang, Jugang Wu, Yantao Cai, Meng Luo, Bing Wang, Yan Gu   +5 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source