Results 201 to 210 of about 3,512,914 (385)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

The Impact of Power Training on Muscle Power, Physical Performance, and Physical Functioning in Older Adults: A Descriptive Case Series

open access: yesClinical Interventions in Aging
Mohamed El Hadouchi,1– 4 Henri Kiers,1,2 Cindy Veenhof,2,5 Jaap Van Dieën3 1Institute for Human Movement Studies, University of Applied Sciences Utrecht, Utrecht, the Netherlands; 2Research Group Innovation of Human Movement Care, University of Applied ...
El Hadouchi M   +3 more
doaj  

Evaluation of the correlation between base deficit on ABG with outcome in surgical ICU patients in ardabil fatemi hospital [PDF]

open access: yes
Background & Objectives : In recent studies the base deficit was introduced as the clinical tool for assessing the critically ill patients, and to determine their prognosis. This study was aimed to examine whether values of base deficit on admission to a
انتظاری, مسعود   +2 more
core  

Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations

open access: yesDiabetes & Metabolic syndrome: clinical Research & Reviews, 2020
A. Singh   +3 more
semanticscholar   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

open access: yesMolecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella   +18 more
wiley   +1 more source

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