Results 61 to 70 of about 2,487,520 (363)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Serum phosphate level at initiation of dialysis is associated with all-cause mortality: a multicenter prospective cohort study

Renal Failure, 2018
Introduction: As glomerular filtration rate (GFR) decreases, serum phosphate level increases. Previous reports indicated that serum phosphate level was associated with mortality in patients on dialysis.
Akiko Owaki, Daijo Inaguma, Isao Aoyama, Shinichiro Inaba, Shigehisa Koide, Eri Ito, Kazuo Takahashi, Hiroki Hayashi, Midori Hasegawa, Yukio Yuzawa, AICOPP group   +10 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Arterial Stiffness in Cancer Survivors: The Prognostic Value of Estimated Pulse Wave Velocity in US Cancer Population From the National Health and Nutrition Examination Survey 2009 to 2018

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Estimated pulse wave velocity (ePWV), a marker of arterial stiffness, is strongly associated with cardiovascular events and all‐cause death in the general population.
Mustafa Al‐jarshawi, Akhmetzhan Galimzhanov, Marco Zimarino, Islam Y. Elgendy, Carlos Diaz‐Arocutipa, Ofer Kobo, Mamas A. Mamas   +6 more
doaj   +1 more source

THE PROGNOSIS IN PROSTATECTOMY [PDF]

Archives of Surgery, 1921
The subject matter of this article, while largely statistical, has proved most instructive to us, and it is presented with the hope that the proverbial dryness of figures will be less arid in this instance, because of their importance. The material is based for the most part on data which we have collected in the preparation of the chapter on prognosis
Leon Herman, John B. Deaver
openaire   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis

Nature Cancer, 2019
We use deep transfer learning to quantify histopathological patterns across 17,355 hematoxylin and eosin-stained histopathology slide images from 28 cancer types and correlate these with matched genomic, transcriptomic and survival data.
Yu Fu, Alexander W. Jung, Ramón Viñas Torné, Santiago Gonzalez, Harald S. Vöhringer, Artem Shmatko, L. Yates, M. Jimenez-Linan, L. Moore, M. Gerstung   +9 more
semanticscholar   +1 more source

AIRWAYS EAR AND MASTOID BONE DISEASES IN ST.-PETERSBURG (ANALYSIS OF 2003–2009 YEARS)

Вопросы современной педиатрии, 2010
Analysis of morbidity with airways (including pneumonia), ear and mastoid bone diseases in children in 2003–2009 years was performed on the basis of City Organizational-Methodical Center of Assessment and Prognosis of Mother’s and Child’s Health, St ...
S.M. Kharit, O.V. Iozefovich, T.G. Kokareva, N.P. Akincheva   +3 more
doaj   +2 more sources