Results 51 to 60 of about 5,086,656 (300)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen +10 more
wiley +1 more source
Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas
Oncotarget, 2016 The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta ...
Zhao, Yang +10 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Nutrition, 2023 BackgroundSystemic nutritional and inflammatory markers, which are easy to measure are associated with the progression and prognosis of many cancers. Nevertheless, among the various available indicators, optimal prognostic indicators for patients with ...
Shuai Xiang +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BMC Cancer, 2020 Background The prognostic nutritional index (PNI), an immunity and nutrition based prognostic score, was correlated with clinical outcomes in different tumors.
Bin Li +7 more
doaj +1 more source
, 2022 Arno Kornberg, Linda Kaschny, Jennifer Kornberg, Helmut Friess Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Surgery, Munich, GermanyCorrespondence: Arno Kornberg, Technical University of Munich, Medical ...
Kaschny L +3 more
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
New prognosis inflammatory and nutritional indexes: comparison with the Prognostic Inflammatory and Nutritional Index as reference index [PDF]
Critical Care, 2011 The Prognostic Inflammatory and Nutritional Index (PINI) was previously developed to improve the diagnosis and monitoring of patients with inflammation and/or malnutrition in terms of morbidity and mortality risk, especially in ICU patients [1]. The formula includes the determination of four serum protein concentrations: PINI = (C-reactive protein (CRP)
Ziegler, F +5 more
openaire +1 more source
, 2023 Supplemental Material for Low Prognostic Nutritional Index Predicts Adverse Outcomes in Patients With Heart Failure: A Systematic Review and Meta-analysis by Xiaole Zhang, and Yongcai Su in ...
Yongcai Su (14678269) +1 more
core +1 more source