Results 131 to 140 of about 842,511 (301)

Why we do need explainable AI for healthcare

Diagnostic and Prognostic Research
The recent uptake in certified Artificial Intelligence (AI) tools for healthcare applications has renewed the debate around their adoption. Explainable AI, the sub-discipline promising to render AI devices more transparent and trustworthy, has also come ...
Giovanni Cinà, Tabea E. Röber, Rob Goedhart, Ş. İlker Birbil   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Prediction models developed using artificial intelligence: similar predictive performances with highly varying predictions for individuals – an illustration in deep vein thrombosis

Diagnostic and Prognostic Research
Objectives The rise in popularity and off-the-shelf availability of machine learning (ML) and AI-based methodology to develop new prediction models provides developers with ample choices to compare and select the best performing model out of many ...
Maerziya Yusufujiang, Constanza L Andaur Navarro, Johanna AA Damen, Toshihiko Takada, Geert-Jan Geersing, Lotty Hooft, Ewoud Schuit, Karel GM Moons, Valentijn MT de Jong, Maarten van Smeden   +9 more
doaj   +1 more source

Bcl-2 is a prognostic marker in breast cancer independently of the nottingham prognostic index

, 2006
Purpose: Prognostication of breast cancer using clinicopathologic variables, although useful, remains imperfect. Many reports suggest that gene expression profiling can refine the current approach. Alternatively, it has been shown that panels of proteins
Callagy, G. M.
core   +1 more source

Prognostic Value of EndoPredict in Women with Hormone Receptor-Positive, HER2-Negative Invasive Lobular Breast Cancer

, 2020
PURPOSE: Invasive lobular carcinoma (ILC) accounts for approximately 5%-15% of all invasive breast cancer cases. Most of the correlations between multigene assays and patient outcome were derived from studies based on patients with invasive ductal ...
Knauer, M, Filipits, M, Fitzal, F, Dowsett, M, Buus, R, Greil, R, Rudas, M, Kronenwett, R, Cuzick, J, Gnant, M, Sestak, I, Balic, M, Dubsky, P   +12 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Research progress on prognostic factors of gallbladder carcinoma

Journal of Cancer Research and Clinical Oncology
Gallbladder carcinoma is the most common malignant tumor of the biliary system, and has a poor overall prognosis. Poor prognosis in patients with gallbladder carcinoma is associated with the aggressive nature of the tumor, subtle clinical symptoms, ineffective adjuvant treatment, and lack of reliable biomarkers.Therefore, evaluating the prognostic ...
Miao, Wentao, Liu, Feng, Guo, Yarong, Zhang, Rui, Wang, Yan, Xu, Jun   +5 more
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source