Results 121 to 130 of about 842,511 (301)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Development and internal validation of a prediction model for post-COVID-19 condition 2 years after infection—results of the CORFU study

Diagnostic and Prognostic Research
Background A subset of COVID-19 patients develops post-COVID-19 condition (PCC). This condition results in disability in numerous areas of patients’ lives and a reduced health-related quality of life, with societal impact including work absences and ...
Dorthe Odyl Klein, Nick Wilmes, Sophie F Waardenburg, Gouke J Bonsel, Erwin Birnie, Marieke SJN Wintjens, Stella CM Heemskerk, Emma BNJ Janssen, Chahinda Ghossein-Doha, Michiel C Warlé, Lotte MC Jacobs, Bea Hemmen, Jeanine A Verbunt, Bas CT van Bussel, Susanne van Santen, Bas LJH Kietselaer, Gwyneth Jansen, Folkert W Asselbergs, Marijke Linschoten, Juanita A Haagsma, S.M.J van Kuijk, CAPACITY-COVID Collaborative Consortium   +21 more
doaj   +1 more source

A critical analysis of prognostic factors for survival in intermediate and high grade non-Hodgkin's lymphoma. Scotland and Newcastle Lymphoma Group Therapy Working Party

, 1991
Between 1979 and 1987 the Scotland and Newcastle Lymphoma Group registered 972 adults with Working Formulation high or intermediate grade non-Hodgkin's lymphoma.
Leonard, R C, Hayward, R.L., Prescott, Robin J   +2 more
core  

Prognostic Score and Cytogenetic Risk Classification for Chronic Lymphocytic Leukemia Patients: Center for International Blood and Marrow Transplant Research Report.

, 2019
PURPOSE To develop a prognostic model and cytogenetic risk classification for previously treated patients with chronic lymphocytic leukemia (CLL) undergoing reduced intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (HCT ...
Nathan, Sunita,, Sorror, Mohamed L, Kindwall-Keller, Tamila,, Alyea, Edwin,, Agura, Edward,, Saad, Ayman, Ahn, Kwang Woo, Saber, Wael,, Olsson, Richard F, Kharfan-Dabaja, Mohamed A., Marks, David I.,, Kindwall-Keller, Tamila, Uberti, Joseph, Ghosh, Nilanjan, Volpe, Virginia O., Alyea, Edwin, Kim, Haesook T, Sobecks, Ronald,, Schouten, Harry C., Chhabra, Saurabh,, Chhabra, Saurabh, Cahn, Jean-Yves,, Hu, Zhen-Huan,, Mehta, Jayesh, Lazarus, Hillard, Davids, Matthew S, Antin, Joseph H, Kharfan-Dabaja, Mohamed A, Brown, Jennifer R.,, Nishihori, Taiga, Kim, Haesook T.,, Forman, Stephen,, Pawarode, Attaphol,, Bashey, Asad,, Saba, Nakhle,, Reshef, Ran,, Aljurf, Mahmoud,, Nash, Richard, Negrin, Robert,, Beitinjaneh, Amer,, Kim, Haesook T., Schouten, Harry C.,, Giralt, Sergio A, Olsson, Richard F., Inamoto, Yoshihiro, Agura, Edward, Hogan, William,, Hu, Zhen-Huan, Mehta, Jayesh,, Wirk, Baldeep M., Perales, Miguel-Angel,, Volpe, Virginia O, Popat, Uday, Hildebrandt, Gerhard C, Davids, Matthew S., Gergis, Usama,, Forman, Stephen, McGuirk, Joseph,, Yared, Jean,, Solh, Melhem, Hill, Brian T., Negrin, Robert, Brown, Jennifer R., Ganguly, Sid, Gale, Robert Peter, Copelan, Edward A, Marks, David I, Wirk, Baldeep M.,, Nishihori, Taiga,, Langston, Amelia, Yared, Jean, Inamoto, Yoshihiro,, Pidala, Joseph, Hamadani, Mehdi,, Hale, Gregory A, Copelan, Edward A., Copelan, Edward A.,, Popat, Uday,, Marks, David I., Sorror, Mohamed L.,, Davids, Matthew S.,, Uberti, Joseph,, Shadman, Mazyar, Cerny, Jan, Savani, Bipin N., Press, Oliver,, Hill, Brian T, Shadman, Mazyar,, Schouten, Harry C, Sobecks, Ronald, Nash, Richard,, Olsson, Richard, Solh, Melhem,, Olsson, Richard,, Langston, Amelia,, Cerny, Jan,, Gergis, Usama, Devine, Steven,, Savani, Bipin N.,, Hale, Gregory A.,, Grunwald, Michael R., Hale, Gregory A., Brown, Jennifer R, Battiwalla, Minoo, Saber, Wael, Cahn, Jean-Yves, Ganguly, Sid,, Grunwald, Michael R, Sorror, Mohamed L., Beitinjaneh, Amer, Grunwald, Michael R.,, McGuirk, Joseph, Hill, Brian T.,, Bacher, Ulrike, Antin, Joseph H., Giralt, Sergio A.,, Perales, Miguel-Angel, Pidala, Joseph,, Kharfan-Dabaja, Mohamed A.,, Aljurf, Mahmoud, Hildebrandt, Gerhard C., Lazarus, Hillard,, Bashey, Asad, Nathan, Sunita, Giralt, Sergio A., Devine, Steven, Volpe, Virginia O.,, Battiwalla, Minoo,, Hildebrandt, Gerhard C.,, Hogan, William, Antin, Joseph H.,, Wirk, Baldeep M, Press, Oliver, Ahn, Kwang Woo,, Pawarode, Attaphol, Bacher, Ulrike,, Hamadani, Mehdi, Saba, Nakhle, Savani, Bipin N, Reshef, Ran, Gale, Robert Peter,, Ghosh, Nilanjan,, Saad, Ayman,   +142 more
core   +1 more source

Modeling Prognostic Factors in Resectable Pancreatic Adenocarcinomas [PDF]

, 2009
Background: The accurate prognosis for patients with resectable pancreatic adenocarcinomas requires the incorporation of more factors than those included in AJCC TNM system.
Gunnar Hartvigsen, Anagnostou, Valsamo K., Botsis, Taxiarchis, Hripcsak, George, Chunhua Weng, Taxiarchis Botsis, Valsamo K. Anagnostou, Hartvigsen, Gunnar, George Hripcsak, Weng, Chunhua   +9 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Explainable AI in healthcare: to explain, to predict, or to describe?

Diagnostic and Prognostic Research
Explainable Artificial Intelligence (AI) methods are designed to provide information about how AI-based models make predictions. In healthcare, there is a widespread expectation that these methods will provide relevant and accurate information about a ...
Alex Carriero, Anne de Hond, Bram Cappers, Fernando Paulovich, Sanne Abeln, Karel GM Moons, Maarten van Smeden   +6 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Quantifying the versatility of routinely measured prognostic factors

Diagnostic and Prognostic Research
Background Some prognostic factors (PF) are “versatile” insofar as they predict diverse health outcomes (age is an exemplar par excellence). In this study, we sought to quantify the versatility of commonly measured PFs. Methods Participants from the UKB (
Hamish Innes, Philip J Johnson
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source