Results 131 to 140 of about 2,292,592 (309)

Prognostic scores in primary biliary cholangitis

Future Science OA
Aim: Evaluating prognostic scores' utility in predicting ursodeoxycholic acid (UDCA) biochemical response (BR) and long-term liver-related complications in primary biliary cholangitis (PBC) patients. Patients & methods: This retrospective single-center study included 50 predominantly female PBC patients (median age: 56) on UDCA treatment.
Ramzi Tababi, Soumaya Mrabet, Imen Akkari, Raida Harbi, Elhem Ben Jazia   +4 more
openaire   +3 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Is Hemoglobin, Albumin, Lymphocyte, and Platelet Score a Prognostic Indicator in Metastatic Squamous Cell Lung Cancer?

Aim: We aimed to determine the prognosis by using the HALP score as a prognostic marker in patients followed in our clinic due to metastatic lung squamous cell carcinoma (SCC).
Yakup Düzköprü, Çavdar, Eyyüp, Doğan, Özlem, Eren, Tülay, Tülay Eren, Özlem Doğan, Eyyüp Çavdar, Düzköprü, Yakup   +7 more
core   +1 more source

Prognostic Value of Albi Score and Lymphocyte-Associated Inflammation Markers in Advanced Hepatocellular Carcinoma: a Single Centre Retrospective Cross-Sectional Study [PDF]

Aim According to the information obtained from the World Health Organization database, the incidence of hepatocellular carcinoma (HCC) in Turkey increased by 17.78% between the years of 2018 and 2020.
Dogu, Gamze Gokoz, Taliha GÜÇLÜ KANTAR, Semra TAŞ, Gamze Serin ÖZEL, Ozdemir, Melek, Ozel, Gamze Serin, Demirel, Burcin Cakan, Gamze GÖKOZ DOĞU, Bedriye AÇIKGÖZ YILDIZ, Atike Gökçen DEMİRAY, Tolga DOĞAN, Burçin ÇAKAN DEMİREL, Serkan DEĞİRMENCİOĞLU, Dogan, Tolga, Melek ÖZDEMİR, Burcu YAPAR TAŞKÖYLÜ, Arzu YAREN, Taskoylu, Burcu Yapar, Demiray, Atike Gokcen   +18 more
core   +1 more source

Mortality-related Factors in Patients with Malignant Obstructive Jaundice

Acta Medica Indonesiana, 2017
Aim: to obtain survival rate and mortality-related factors of malignant obstructive jaundice patients. Methods: all medical records of obstructive jaundice inpatient at Cipto Mangunkusumo Hospital, Jakarta from January 2010 to December 2013 were reviewed
Juferdy Kurniawan, Irsan Hasan, Rino Alvani Gani, Marcellus Simadibrata   +3 more
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