Results 111 to 120 of about 2,292,592 (309)

Construction of nomogram model of poor prognosis for patients newly diagnosed with brain metastasis from non-small cell lung cancer based on clinical pathology and prognostic scores

Frontiers in Oncology
ObjectiveTo explore non-small cell lung cancer (NSCLC) patients with new diagnosis of brain metastasis and construct Logistic regression model based on clinical pathology and prognosis score, and verify.MethodsA total of 158 patients newly diagnosed with
Zengliang Li, Zengliang Li, Xiaoyue Wang, Xiaoyue Wang, Guodong Ma, Guodong Ma   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Predictive performance of the SOFA 2.0 score for in-hospital mortality in patients with heat stroke: a multicenter, data-driven subphenotype study

Frontiers in Medicine
ObjectiveHeat stroke can progress rapidly, and the risk of in-hospital mortality increases once multiple organ dysfunction develops. Early risk stratification is therefore clinically important, yet comparative evidence across commonly used severity ...
Haoming Luo, Yirui Zhu, Tongtong Wang, Weihua Li, Haiyang Guo, Chen Ting, Yuanyuan Ou, Mengshan Guan, Yifeng Zhang, Guoxuan Lin, Zhiguo Pan, Zhiguo Pan, Anwei Liu, Anwei Liu   +13 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines [PDF]

, 2009
Background: Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty. The multiply imputed datasets are each analysed using
Holder, Roger, Douglas G Altman, Altman Douglas G, Holder, RL, Royston, Patrick, Royston, P, Marshall, A, Patrick Royston, Marshall Andrea, Holder, Roger L., Roger L Holder, Altman, DG, Altman, Douglas G., Royston Patrick, Andrea Marshall, Marshall, A. (Andrea), Holder Roger L, Altman, Doug   +17 more
core   +2 more sources

Development and validation of a novel hepato-metabolic-renal score nomogram for predicting disease-free survival in head and neck squamous cell carcinoma

Frontiers in Oncology
BackgroundHead and neck squamous cell carcinoma (HNSCC) exhibits marked heterogeneity in disease-free survival (DFS), highlighting the need for improved prognostic tools.
Lu Lu, Yue Chen, Shudong An, Nuoxuan Niu, Qian Chen, Xinyu Ban, Shuyan Liu, Shiyang Wang, Xiaorong Zhang, Yanqiang Wei, Lan Yao, Yanxia Bai   +11 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Achilles tendon total rupture score : a study of responsiveness, internal consistency and convergent validity on patients with acute Achilles tendon ruptures [PDF]

, 2012
Background The Achilles tendon Total Rupture Score was developed by a research group in 2007 in response to the need for a patient reported outcome measure for this patient population.
Costa, Matthew L., Lamb, S. E. (Sallie E.), Parsons, Nicholas R., Kearney, Rebecca S., Achten, Juul, Achten, J, Lamb, Sarah, Costa, ML, Kearney Rebecca S, Achten Juul, Parsons, N, Lamb Sarah E, Parsons Nicholas, Costa Matthew L, Kearney, RS, Lamb, SE   +15 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source