Results 91 to 100 of about 2,292,592 (309)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Modified Naples Prognostic Score for Postoperative Prognostic Stratification in Patients with Oral Squamous Cell Carcinoma [PDF]

Jingyi Ran, Yalian Liu, Xiaoxi Yi, Fujun Zhang Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Fujun Zhang, Department of Oral and ...
Liu Y, Zhang F, Yi X, Ran J
core  

Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures [PDF]

, 2011
Background: Current prognostic gene signatures for breast cancer mainly reflect proliferation status and have limited value in triple-negative (TNBC) cancers.
Pusztai, Lajos, Lajos Pusztai, Schmidt Marcus, Karn, Thomas, Lars Hanker, Holtrich Uwe, Ruckhäberle Eugen, Volkmar Müller, Liedtke, Cornelia, Karn Thomas, Shiang Christine Y., Rody Achim, Gätje, Regine, Solbach Christine, Eugen Ruckhäberle, Pusztai Lajos, Müller, Volkmar, Cornelia Liedtke, Rody, Achim, Ahr Andre, Ruckhäberle, Eugen, Marcus Schmidt, Christine Y Shiang, Solbach, Christine, Gaetje Regine, Ahr, André, Andre Ahr, Thomas Karn, Hanker Lars, Achim Rody, Schmidt, Marcus, Shiang, Christine Y., Hanker, Lars, Takayuki Iwamoto, Holtrich, Uwe, Iwamoto Takayuki, Manfred Kaufmann, Liedtke Cornelia, Uwe Holtrich, Christine Solbach, Müller Volkmar, Iwamoto, Takayuki, Kaufmann Manfred, Kaufmann, Manfred, Regine Gaetje   +44 more
core   +1 more source

Prognostic values of SOFA score, qSOFA score, and LODS score for patients with sepsis

Annals of Palliative Medicine, 2020
Sepsis continues to carry a high rate of mortality, which makes effective and simple evaluation methods for predicting the prognosis of septic patients especially important. In this study, we retrospectively analyzed the relationships between three scoring systems including Sequential Organ Failure Assessment (SOFA) score, Quick SOFA (qSOFA) score, and
Yonglin, Li, Chunjiang, Yan, Ziyan, Gan, Xiaotu, Xi, Zhanpeng, Tan, Jun, Li, Guowei, Li   +6 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Prognostic value of the Glasgow prognostic score in colorectal cancer: a meta-analysis of 9,839 patients

, 2018
Xin Lu,1 Wanying Guo,2 Wei Xu,1 Xuelei Zhang,1 Zhijie Shi,1 Leizhen Zheng,1 Wenzhao Zhao1 1Department of Gastrointestinal Surgery, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang ...
Lu X, Guo W, Zhang X, Zheng L, Zhao W, Shi Z, Xu W   +6 more
core  

What defines 'cure' after liver resection for colorectal metastases? Results after 10 years of follow-up [PDF]

, 2010
Background: During the last two decades, resection of colorectal liver metastases (CLM) in selected patients has become the standard of care, with 5-year survival rates of 25-58%.
Parks, Rowan W.; id_orcid, Aldrighetti, Luca, Garden, O. James, Parks, Rowan W., Bodingbauer, Martin, Wigmore, Stephen J., Castillo, Federico, Ferla, Gianfranco, Pulitano, Carlo   +8 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

TBA-MLR score: a metabolic-immune prognostic biomarker for postoperative hepatocellular carcinoma

Frontiers in Immunology
ObjectiveTo develop and validate a novel prognostic score combining serum total bile acid (TBA) and monocyte-to-lymphocyte ratio (MLR) for improved risk stratification in hepatocellular carcinoma (HCC) patients after radical hepatectomy.MethodsIn 508 HCC
Yuanquan Zhao, Wei Huang, Xiwen Deng, Pengyang Li, Siyang Yao, Yongyu Yang, Xiaofeng Dong   +6 more
doaj   +1 more source