Results 81 to 90 of about 2,292,592 (309)

Potential clinically useful prognostic biomarkers in triple-negative breast cancer: preliminary results of a retrospective analysis

Breast Cancer: Targets and Therapy, 2018
Silvia Mihaela Ilie,1 Xenia Elena Bacinschi,1,2 Inga Botnariuc,2 Rodica Maricela Anghel1,2 1University of Medicine and Pharmacy “Carol Davila,” Bucharest, Romania; 2Department of Oncology-Radiotherapy, Institute of Oncology “Prof Dr ...
Ilie SM, Bacinschi XE, Botnariuc I, Anghel RM   +3 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Machine learning-derived AS and AIS scores leverage BCAA metabolism and IL4I1 activity for prognosis and tailored therapy in ccRCC

Frontiers in Cell and Developmental Biology
Background and objectiveRenal cell carcinoma (RCC) is among the most prevalent malignant tumors globally, characterized by a poor prognosis. The 5-year survival rate for advanced clear cell renal cell carcinoma (ccRCC) is below 20%.Materials and ...
Kang Qiang Weng, Xin Li, Xiao bao Chen, Jun wei Lin, Ling jun Liu, Le ye Yan, Ruo yun Xie   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery [PDF]

, 2014
Background:Wider clinical applications of 9p status in clear cell renal cell carcinoma (ccRCC) are limited owing to the lack of validation and consensus for interphase fluorescent in situ hybridisation (I-FISH) scoring technique.
Fleming, S., P Rauchhaus, J Fitzpatrick, Fitzpatrick, J., N Pratt, S Fleming, J Bondad, J Cunningham, El-Mokadem, I., Cunningham, J., Bondad, J., Nabi, G., Rauchhaus, P., G Nabi, Pratt, N., I El-Mokadem   +15 more
core   +1 more source

Inflammation-tumor burden interaction score stratifies survival after irinotecan-eluting bead chemoembolization for colorectal liver metastases

Frontiers in Medicine
BackgroundTransarterial chemoembolization with irinotecan-loaded drug-eluting beads is an established locoregional option for selected patients with colorectal liver metastases who are not candidates for resection or ablation, but survival outcomes ...
Tolga Doğan, Semra Taş, Emre Hafızoğlu, Taliha Güçlü Kantar, Burçin Çakan Demirel, Emre İspir, Erdem Çomut, Muhammet Arslan, Burcu Yapar Taşköylü, Atike Gökçen Demiray, Arzu Yaren, Gamze Gököz Doğu   +11 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Genetic Variants Associated with Life Expectancy in Patients with Chagas Disease

Medical Sciences
Single nucleotide polymorphisms (SNPs), as common genetic variations, can influence biological processes. Identifying these variations is crucial for recognizing high-risk subgroups, guiding preventive strategies, and enabling personalized management ...
Mario Bruno Principato, Maria Victoria Carvelli, Analia Paolucci, Camila Principato, Rocio Villa Fernandez, Nicolas Aguirre, Gabriel Ercoli, Guillermo Alberto Keller, Guillermo Di Girolamo, Manuel Lago, Justo Carbajales   +10 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Prognostic indicators of early and late death in children admitted to district hospital in Kenya: cohort study [PDF]

, 2003
OBJECTIVES: To identify clinical indicators of immediate, early, and late mortality in children at admission to a sub-Saharan district hospital and to develop prognostic scores. DESIGN: Prospective cohort study.
Osier, FH, Ross, A, Marsh, K, Shebbe, M, Berkley, James A, Berkley, JA, Mwangi, I, Osier, F.H.A., Lowe, BS, Mohammed, M, Marsh, Kevin, Newton, Charles R.J.C., Newton, CR, Lowe, B.S.   +13 more
core   +1 more source