Results 101 to 110 of about 2,292,592 (309)

Prognostication of Follicular Lymphoma: A Review of Prognostic Scores and Factors

Diagnostics
Follicular lymphoma (FL) is an indolent, rarely curable B-cell malignancy with a heterogeneous clinical course. While generally treatable, FL is characterized by remissions and relapses, and its clinical presentation varies widely. Rituximab has revolutionized FL treatment, significantly improving overall survival over the past two decades.
Ádám Jóna, Evelin Kiss, Árpád Illés   +2 more
openaire   +3 more sources

Letter: prognostic scores in alcoholic hepatitis [PDF]

Alimentary Pharmacology & Therapeutics, 2014
patients when restricted to those with baseline viral loads >9 log10 copies/mL. Second, our study focused on a real-life treatment setting; this is in contrast to a clinical trial, in which treatment protocols are followed much more rigorously and higher response rates are expected.
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Maximum tumor diameter is not an independent prognostic factor in high-risk localized prostate cancer. [PDF]

, 2008
Contains fulltext : 69173.pdf (Publisher’s version ) (Open Access)OBJECTIVES: Previous studies suggest that maximum tumor diameter (MTD) is a predictor of recurrence in prostate cancer (PC).
C. A. Hulsbergen-vandeKaa, Oort, I.M. van, L. A. L. M. Kiemeney, Kok, D.E.G., D. E. G. Kok, van Oort, I.M., I. M. van Oort, Kok, D.E., Kiemeney, L.A.L.M., Hulsbergen-van de Kaa, C.A., Kiemeney, L.A., Oort, I.M., van, Witjes, J.A., J. A. Witjes   +13 more
core   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Implementation of the Phoenix Sepsis Score in Vietnamese Pediatric Patients: Prognostic Accuracy and Comparative Analysis with Neutrophil- Lymphocyte Ratio [PDF]

Introduction: To evaluate the implementation of the Phoenix sepsis score in the prognosis of pediatric sepsis, and to compare the prognostic accuracy of the Phoenix with that of the NLR.
Chau Duc Nguyen-Huu, Bich-Ngoc Phan, Van-Tuy Nguyen   +2 more
core   +1 more source

Development and Multicentre Validation of the Modena Score to Predict Survival in Advanced Biliary Cancers Undergoing Second-Line Chemotherapy

Cancer Management and Research, 2022
Massimiliano Salati,1,2 Luigi Marcheselli,1 Carlo Messina,3 Valeria Merz,3,4 Marco Messina,5 Pietro Carotenuto,6 Francesco Caputo,1 Fabio Gelsomino,1 Andrea Spallanzani,1 Luca Reggiani Bonetti,7 Stefania Caramaschi,7 Gabriele Luppi,1 Massimo Dominici,1 ...
Salati M, Marcheselli L, Messina C, Merz V, Messina M, Carotenuto P, Caputo F, Gelsomino F, Spallanzani A, Reggaiani Bonetti L, Caramaschi S, Luppi G, Dominici M, Ghidini M   +13 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Tumor‐infiltrating immune cell score as an independent prognostic predictor for endometrial carcinoma: Insights from a comprehensive analysis of the immune landscape

Cancer Reports
Background Immune cells are crucial components in the tumor microenvironment and have a significant impact on the outcomes of patients. Aims Here, we aimed to establish a prognostic score based on different types of tumor‐infiltrating immune cells for ...
Liping Zhang, Qiaoying Zhu, Qi Zhao, Xueping Lin, Hui Song, Hong Liu, Guiquan Zhu, Shun Lu, Bangrong Cao   +8 more
doaj   +1 more source