Results 121 to 130 of about 20,667,655 (317)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Delineation and agreement of FET PET biological volumes in glioblastoma: results of the nuclear medicine credentialing program from the prospective, multi-centre trial evaluating FET PET In Glioblastoma (FIG) study—TROG 18.06 [PDF]

, 2023
Nathaniel Barry, Roslyn J. Francis, Martin A. Ebert, Eng‐Siew Koh, Pejman Rowshanfarzad, Ghulam Mubashar Hassan, Jake Kendrick, Hui Gan, Sze T. Lee, Eddie Lau, Bradford A. Moffat, Greg Fitt, Alisha Moore, Paul Thomas, David A. Pattison, Tim Akhurst, Ramin Alipour, E. Louise Thomas, Edward Hsiao, Geoffrey Schembri, Peter Lin, Tam Ly, June Yap, Ian Kirkwood, Wilson Vallat, Shahroz Khan, Dayanethee Krishna, Stanley Ngai, Christopher Yu, Scott Beuzeville, Tow C. Yeow, Dale L. Bailey, Olivia Cook, Angela Whitehead, Rachael Dykyj, Alana Rossi, Andrew Grose, Andrew M. Scott   +37 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Effects of Health Education Programs for the Elders in Community Care Centers – Evaluated by Health Promotion Behaviors

, 2017
Kuo-Song Chang, Wen-Hsiang Tsai, Cheng-Ho Tsai, Hung‐I Yeh, Po-Hao Chiu, Ya‐Wen Chang, Hsin‐Yung Chen, Jung‐Mei Tsai, Shu-Chen Lee   +8 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Editorial: New Approaches to Radiation-Therapeutic Agent Cancer Care for Women

Frontiers in Oncology, 2017
Charles A. Kunos, Elise C. Kohn
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

AN IMPLEMENTATION EVALUATION OF A PEER-LED HEALTH PROMOTION PROGRAM FOR SENIORS WITH FEAR OF FALLING [PDF]

, 2017
Agathe Lorthios-Guilledroit, Johanne Filiatrault, Lucie Richard   +2 more
openalex   +1 more source

Causal Spousal Health Spillover Effects and Implications for Program Evaluation.

American Economic Journal: Economic Policy, 2017
Jason M. Fletcher, R. Marksteiner
semanticscholar   +1 more source