Results 211 to 220 of about 4,968,629 (297)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

CDC Program Evaluation Framework, 2024. [PDF]

MMWR Recomm Rep
Kidder DP, Fierro LA, Luna E, Salvaggio H, McWhorter A, Bowen SA, Murphy-Hoefer R, Thigpen S, Alexander D, Armstead TL, August E, Bruce D, Clarke SN, Davis C, Downes A, Gill S, House LD, Kerzner M, Kun K, Mumford K, Robin L, Schlueter D, Schooley M, Valverde E, Vo L, Williams D, Young K, CDC Evaluation Framework Work Group, CDC Evaluation Framework Work Group Members.   +28 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Improving perinatal mood and anxiety disorders through integrated infant mental health care in obstetrics: evidence from a program evaluation study. [PDF]

BMC Pregnancy Childbirth
Jester JM, Hoffman CM, Issa M, Riggs JL, O'Neill H, Duprey M, Rosenblum K, Erickson NL, Bengel C, Fisk C, Muzik M.   +10 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Creation and Program Evaluation of a Women in Surgery in ENT (WISE) Group. [PDF]

J Otolaryngol Head Neck Surg
Oulousian E, Graham ME, Chan Y, Lea J, Hu A.   +4 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

A New Era for Maternal and Child Nutrition Implementation Science Research and Program Evaluation. [PDF]

Matern Child Nutr
Pérez-Escamilla R, Moran VH.
europepmc   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Health Educators and Academic Leaders: A Developmental, Principles-Focused Program Evaluation Approach for Aspiring Clinician Educators in Graduate Medical Education. [PDF]

J Grad Med Educ
Rohlfsen C, Hall J, Howell MC, Hershberger DM, Ashford AK, Mullane R, Gollehon N, Custer T, Thompson H, Armijo PR.   +9 more
europepmc   +1 more source