Results 31 to 40 of about 13,873 (186)

Notes al voltant de la informació a Orient Mitjà [PDF]

, 1995
Notes al voltant de la informació a Orient ...
Alcoverro, Tomàs
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Beneficis de l'envelliment actiu en la memòria; realitat o utopia? Incidència de l'activitat quotidiana en la memòria de treball [PDF]

, 2016
A través d'aquest estudi es cerquen les possibles diferències entre ancians actius i no actius pel que fa al seu rendiment en tasques de memòria de treball i, per tant, estudiar la importància que pren l'envelliment actiu en un millor manteniment de la ...
Insa Montero, Elisabet, Universitat Autònoma de Barcelona. Facultat de Psicologia   +1 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Food Addiction in Eating Disorders: A Cluster Analysis Approach and Treatment Outcome. [PDF]

Nutrients, 2022
Munguía L, Gaspar-Pérez A, Jiménez-Murcia S, Granero R, Sánchez I, Vintró-Alcaraz C, Diéguez C, Gearhardt AN, Fernández-Aranda F.   +8 more
europepmc   +1 more source

Anàlisi del condicionament físic dels bombers en funció de l’edat [PDF]

, 2013
Introducció: Els bombers han de tenir un estat de forma excel·lent per desenvolupar amb seguretat l’activitat professional. Els objectius d’aquest treball són descriure les característiques antropomètriques i el condicionament físic de 2 grups de bombers
García Franco, José, Lara Sánchez, Amador, Torres-Luque, Gema, Zagalaz Sánchez, María   +3 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

How Did the COVID-19 Lockdown Pandemic Affect the Depression Symptomatology in Mediterranean Older Adults with Metabolic Syndrome? [PDF]

Depress Anxiety, 2023
Paz-Graniel I, Babio N, Nishi SK, Martínez-González MÁ, Corella D, Fitó M, Martínez A, Alonso-Gómez ÁM, Wärnberg J, Vioque J, Romaguera D, López-Miranda J, Estruch R, Tinahones FJ, Santos-Lozano JM, Serra-Majem JL, Bueno-Cavanillas A, Tur JA, Sánchez VM, Pintó X, Delgado-Rodríguez M, Matía-Martín P, Vidal J, Calderon-Sanchez C, Daimiel L, Ros E, Fernández-Aranda F, Toledo E, Valle-Hita C, Sorli JV, Lassale C, Garcia-Rios A, Oncina-Canovas A, Barón-López FJ, Zulet MA, Rayó E, Casas R, Thomas-Carazo E, Tojal-Sierra L, Damas-Fuentes M, Ruiz-Canela M, De Las Heras-Delgado S, Fernandez-Carrión R, Castañer O, Peña-Orihuela PJ, Gonzalez-Palacios S, Buil-Cosiales P, Goday A, Salas-Salvadó J.   +48 more
europepmc   +1 more source