Results 261 to 270 of about 212,261 (301)
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Programmed death ligand 1 signals in cancer cells
Nature Reviews Cancer, 2022The paradigm of surface-expressed programmed death ligand 1 (PDL1) signalling to immune cell programmed death 1 (PD1) to inhibit antitumour immunity has helped to develop effective and revolutionary immunotherapies using antibodies blocking these cell-extrinsic interactions.
Anand V. R. Kornepati +2 more
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Resistance mechanisms to programmed cell death protein 1 and programmed death ligand 1 inhibitors
Expert Opinion on Biological Therapy, 2021Introduction: In the past few years, administrating monoclonal humanized antibodies, namely checkpoint inhibitors, against programmed cell death protein 1 (PD-1), and its ligand (PD-L1), has yielded reassuring tumor regression rates. Anti-PD-1/PD-L1 checkpoint inhibitors disrupt the engagement of PD-1 on T-cells and their ligands on tumor or other ...
Parmida Sadat Pezeshki +2 more
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Programmed Cell Death–Ligand 1 Overexpression in Thyroid Cancer
Endocrine Practice, 2019Programmed cell death-ligand 1 (PD-L1) expression on tumor tissue has been associated with favorable response to anti-programmed cell death-receptor 1/PD-L1 therapy in many human cancers. Studies have reported that PD-L1 is also expressed in thyroid cancer.
Guo-Qiang, Zhang +8 more
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Expression of programmed cell death ligand 1 and programmed cell death 1 in cutaneous warts
Journal of the American Academy of Dermatology, 2019Cutaneous warts have high prevalence and cause significant morbidity. Understanding the mechanisms by which warts evade the immune system could lead to targeted and improved treatments.To determine whether cutaneous warts express programmed cell death ligand 1 (PD-L1) and to characterize the expression of programmed cell death 1 (PD-1) within the ...
Wesley Y, Yu +4 more
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The worsening impact of programmed cell death ligand 1 in ovarian clear cell carcinomas
Archives of Gynecology and Obstetrics, 2022To investigate the clinical significance of programmed cell death ligand 1 (PD-L1) expression in ovarian clear cell carcinoma (CCC).Patients with CCC who underwent primary surgery at our hospital between 1984 and 2014 were enrolled in this study. PD-L1 and mismatch repair (MMR) protein expression in tumor cells, tumor-infiltrating lymphocytes (TILs ...
Hiroko Matsuura +10 more
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Journal of Medicinal Chemistry, 2018
The clinical success of inhibitors targeting the PD-1/PD-L1 pathway has made this an active field in cancer immunotherapy. Currently, most drugs targeting this pathway are monoclonal antibodies. Small-molecule inhibitors as the alternative to monoclonal antibodies are expected to overcome the disadvantages of mAbs which include production difficulties ...
Tianyu Wang +6 more
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The clinical success of inhibitors targeting the PD-1/PD-L1 pathway has made this an active field in cancer immunotherapy. Currently, most drugs targeting this pathway are monoclonal antibodies. Small-molecule inhibitors as the alternative to monoclonal antibodies are expected to overcome the disadvantages of mAbs which include production difficulties ...
Tianyu Wang +6 more
openaire +2 more sources
Fibroblast Programmed Cell Death Ligand 1 Promotes Osteoclastogenesis in Odontogenic Keratocysts
The American Journal of Pathology, 2023Local aggressive growth of odontogenic keratocysts (OKCs) can cause serious bone destruction, even resulting in pathologic fractures of the mandible. The mechanism of osteoclastogenesis in OKCs was explored by investigating the role of programmed cell death ligand 1 (PD-L1), a key immune checkpoint, in OKCs and its relationship with the M2 isoform of ...
Tianshuang Zhu +8 more
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Prognostic relevance of programmed cell death ligand 1 expression in glioblastoma
Journal of Neuro-Oncology, 2017The aim of this study was to determine the clinicopathological significance of programmed cell death ligand 1 (PD-L1) expression in glioblastoma (GBM). In a retrospective cohort of 115 consecutive patients with GBM, PD-L1 expression was determined using immunohistochemistry (IHC).
Kyu Sang Lee +8 more
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Comparative analysis of programmed cell death ligand 1 assays in renal cell carcinoma
Histopathology, 2020AimsThe importance of programmed cell death ligand 1 (PD‐L1) expression has emerged in clinical trials of PD‐L1 target therapy in renal cell carcinoma (RCC). This study compares PD‐L1 assays in RCC.Methods and resultsTwo US Food and Drug Administration‐approved PD‐L1 assays (22C3 and SP142) and one research‐use only antibody (E1L3N) were used in a ...
Kyu Sang Lee +8 more
openaire +2 more sources