Results 271 to 280 of about 212,261 (301)

Alcohol induces programmed death receptor-1 and programmed death-ligand-1 differentially in neuroimmune cells

Alcohol, 2020
Engagement of programmed death-1 (PD-1) receptor by its ligands (PD-L1/PD-L2) in activated immune cells is known to be involved in inflammatory neurological disease via a co-inhibitory signal pathway. Interaction of PD-1/PD-L1 is believed to occur only in activated neuroimmune cells because there are undetectable levels of PD-1/PD-L1 in normal ...
Vikas Mishra, Agnieszka Agas, Heather Schuetz, Jagathi Kalluru, James Haorah   +4 more
openaire   +2 more sources

Programmed cell death ligand‐1: A dynamic immune checkpoint in cancer therapy

Chemical Biology & Drug Design, 2020
AbstractAntibody‐based immunotherapies play a pivotal role in cancer research with efficient achievements in tumor suppression. Tumor survival is assisted by modulation of immune checkpoints to create imbalances between immune cells and cancer cell's environment.
Muhammad Kalim, Muhammad Saleem Iqbal Khan, Jinbiao Zhan   +2 more
openaire   +2 more sources

Programmed cell death ligand-1 expression in gastroenteropancreatic neuroendocrine tumors.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2019
Gastroenteropancreatic tumors (GEPNETs) is a heterogeneous disease with variable clinical course. While promising therapeutic options exist for other adult cancers, there are no new molecular-based treatments developed for GEPNETs. One of the main targets of cancer immunotherapy is the Programmed Cell Death Ligand-1 (PD-L1) pathway.
Oktay, Esin, Yalcin, Gizem Donmez, Ekmekci, Sumeyye, Kahraman, Dudu Solakoglu, Yalcin, Abdullah, Degirmenci, Mustafa, Dirican, Ahmet, Altin, Zeynep, Ozdemir, Ozlem, Surmeli, Zeki, Diniz, Gulden, Ayhan, Semin, Bulut, Gulcan, Erdogan, Atike, Uslu, Ruchan   +14 more
openaire   +3 more sources

Immunotherapy With Programmed Cell Death 1 vs Programmed Cell Death Ligand 1 Inhibitors in Patients With Cancer

JAMA Oncology, 2020
Tao, Wang, Shiowjen, Lee, Gerald M, Feldman   +2 more
  +9 more sources

Expression of programmed cell death protein 1 and programmed cell death ligand 1 in feline injection site fibrosarcomas

Research in Veterinary Science
Feline injection site fibrosarcomas represent a unique challenge in veterinary oncology due to their association with injection sites and aggressive behaviour. The study explores the expression of immune checkpoints programmed cell death protein 1 and programmed cell death ligand 1 in the malignancy, aiming to unravel their potential significance in ...
Mateusz, Mikiewicz, Katarzyna, Paździor-Czapula, Joanna, Fiedorowicz, Iwona, Otrocka-Domagała   +3 more
openaire   +2 more sources

Clinical impact of programmed cell death ligand 1 expression in colorectal cancer

European Journal of Cancer, 2013
Programmed cell death 1 (PD-1) receptor triggering by PD ligand 1 (PD-L1) inhibits T cell activation. PD-L1 expression was detected in different malignancies and associated with poor prognosis. Therapeutic antibodies inhibiting PD-1/PD-L1 interaction have been developed.A tissue microarray (n=1491) including healthy colon mucosa and clinically ...
Droeser RA, Hirt C, Viehl CT, Frey DM, Nebiker C, Huber X, Zlobec I, EppenbergerCastori S, Tzankov A, Rosso R, Zuber M, Muraro MG, Amicarella F, Cremonesi E, Heberer M, Iezzi G, Lugli A, Terracciano L, Sconocchia G, Oertli D, Spagnoli GC, Tornillo L   +21 more
openaire   +6 more sources

Prognostic Significance of Programmed Cell Death-1, Programmed Cell Death-Ligand 1, Programmed Cell Death-Ligand 2, and Fibroblast Growth Factor Receptor 3 mRNA Expression in Bladder Cancer

Pathobiology
Introduction: This study aimed to evaluate the prognostic significance of programmed cell death (PD)-1/PD-ligand 1 (PD-L1), PD-ligand 2 (PD-L2), and fibroblast growth factor receptor 3 (FGFR3) expression in bladder cancer (BC). Methods: A retrospective study was conducted on BC patients who underwent transurethral resection between 2005 and 2014.
Ana Blanca, Antonio Lopez-Beltran, Enrique Gomez-Gomez, Pablo Campos-Hernández, Alessia Cimadamore, Rodolfo Montironi, Liang Cheng   +6 more
openaire   +3 more sources

Programmed Cell Death-Ligand 1 (PD-L1) Expression in Anal Cancer

American Journal of Clinical Oncology, 2018
Objective: To evaluate the expression of programmed cell death-ligand 1 (PD-L1) in anal cancer. Patients and Methods: In a retrospective cohort analysis, subjects with squamous cell carcinoma of the anal canal were tested for PD-L1 expression, then followed for recurrence and ...
Rangaswamy, Govindarajan, Swetha, Gujja, Eric R, Siegel, Anu, Batra, Anwaar, Saeed, Keith, Lai, Jennifer D, James, Bradley J, Fogel, Stephen, Williamson   +8 more
openaire   +2 more sources

There Is an Unmet Need for Another Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Inhibitor

Journal of Thoracic Oncology, 2022
Jamie, Feng, Natasha B, Leighl
openaire   +2 more sources

Characterization of feline programmed cell death 1 and programmed cell death ligand 1

Programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) interact to regulate T cell biology. However, during infection with the human immunodeficiency virus (HIV), aberrant PD molecule expression contributes to pathological immune suppression.
openaire   +1 more source