Moving forward to address key unanswered questions on targeting PD-1/PD-L1 in cancer: limitations in preclinical models and the need to incorporate human modifying factors. [PDF]
, 2019 The tremendous clinical success of immune checkpoint inhibition (ICI), particularly targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1/2 (PD-L1/2) pathway, has resulted in application to multiple cancers, as a monotherapy and ...
Le, Catherine T, Murphy, William J
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Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death [PDF]
, 1992 MA Brach +3 more
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Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets
MedCommProgrammed cell death represents a precisely regulated and active cellular demise, governed by a complex network of specific genes and proteins. The identification of multiple forms of programmed cell death has significantly advanced the understanding of
Shen'er Qian +7 more
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The Molecular Links between Cell Death and Inflammasome
Cells, 2019 Programmed cell death pathways and inflammasome activation pathways can be genetically and functionally separated. Inflammasomes are specialized protein complexes that process pro-inflammatory cytokines, interleukin-1β (IL-1β), and IL-18 to ...
Kwang-Ho Lee, Tae-Bong Kang
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Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Which one of the types of programmed cell death is reduced by aerobic exercise? [PDF]
Journal of Exercise & Organ Cross TalkProgrammed cell death is a critical element of the body’s defense system. Exercise represents a physiological stressor that triggers an adaptive response within the body. It has been suggested that various forms of programmed cell death are essential for
Peyman Akraminia +3 more
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PDCD5 interacts with p53 and functions as a regulator of p53 dynamics in the DNA damage response [PDF]
arXiv, 2015 The tumor suppressor p53 plays a central role in cell fate decisions after DNA damage. Programmed Cell Death 5 (PDCD5) is known to interact with the p53 pathway to promote cell apoptosis. Recombinant human PDCD5 can significantly sensitize different cancers to chemotherapies.
arxiv
Nucleic acid sensors and programmed cell death [PDF]
, 2020 Liverpool, Layal +2 more
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Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells. [PDF]
, 1993 Apurva Sarin +2 more
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