Results 111 to 120 of about 6,837,118 (237)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Analysis of the "engrailed"-expressing neuroblast lineages in "Drosophila" brain development [PDF]
, 2009 The segment polarity gene engrailed (en) encodes a homeodomain transcription factor which is expressed in metamerically reiterated stripes in the embryonic neuroectoderm, in some primary neuroblasts and their progeny; usually located at the posterior ...
Kumar, Abhilasha
core +1 more source
Journal of the Pakistan Medical AssociationObjective: To determine the immunohistochemical expression of Programmed cell Death Ligand 1 and intratumoural cluster of differentiation-8-positive T lymphocyte count in primary breast cancer cases, and to ascertain their association with different ...
Sayher Kazmi +2 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Programmed cell death in the nervous system—a programmed cell fate?
Current Opinion in Neurobiology, 2009 Studies of developmental cell death in the nervous system have revealed two different modes of programmed cell death (PCD). One results from competition for target-derived trophic factors and leads to the stochastic removal of neurons and/or glia.
Miguel-Aliaga, Irene, Thor, Stefan
openaire +7 more sources
Studies of cell migration and programmed cell death: characterization and analysis of scattershot, a mutation disrupting germ cell migration and programmed cell death in Drosophila melanogaster [PDF]
, 2008 Cell migration is a process critical to development, wound healing, immune response and defects in this process are the cause of many disease states. Elucidating the molecular mechanisms and signal transduction cascades mediating this process is crucial ...
Kamps, Angela
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Editorial: Plant Programmed Cell Death Revisited
Frontiers in Plant Science, 2021 Joanna Kacprzyk +3 more
doaj +1 more source
Neural Regeneration ResearchCentral nervous system injuries have a high rate of resulting in disability and mortality; however, at present, effective treatments are lacking. Programmed cell death, which is a genetically determined form of active and ordered cell death with many ...
Li Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source