Results 61 to 70 of about 1,266,471 (355)

Targeting BCL-2 regulated apoptosis in cancer [PDF]

, 2018
The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death ...
Campbell, Kirsteen J., Tait, Stephen W.J.   +1 more
core   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton

Haematologica, 2009
Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death.
Sandrine Barbier, Laurent Chatre, Marlène Bras, Patricia Sancho, Gaël Roué, Clémence Virely, Victor J. Yuste, Sylvie Baudet, Manuel Rubio, Josep E. Esquerda, Marika Sarfati, Hélène Merle-Béral, Santos A. Susin   +12 more
doaj   +1 more source

Apoptosis - Programmed Cell Death [PDF]

, 2003
Tijekom evolucije višestanični organizmi uspjeli su razviti različite mehanizme zaštite od djelovanja štetnih utjecaja iz okoline. Apoptoza ili “programirana smrt stanice” jedan je od tih mehanizama kojim stanica aktivno uz utrošak energije i sintezu ...
Vilim Žlender
core   +1 more source

Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death. [PDF]

, 2020
Timely sister chromatid separation, promoted by separase, is essential for faithful chromosome segregation. Separase is a member of the CD clan of cysteine proteases, which also includes the pro-apoptotic enzymes known as caspases.
Jeong, Pan Young, Joshi, Pradeep M, Kumar, Ashish, Rothman, Joel H   +3 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Assessment of programmed cell death 1 and its programmed cell death ligand 1 levels in vitiligo

Journal of the Egyptian Women’s Dermatologic Society
Background Programmed cell death 1 (PD-1) is a cell surface protein that serves as an immune checkpoint in conjunction with its two ligands, PD-L1 and PD-L2.
Hanan R. Nada, Ahmed Mourad, Laila A. Rashed, Ghada M. El-Hanafy, Nermeen M.A. Abdallah, Mohamed M. Abdelhady   +5 more
doaj   +1 more source

Сell death and its significance in reproductive pathology

Ukrainian Journal of Veterinary and Agricultural Sciences, 2021
Since the middle of the last century, scientists have been interested in the mechanisms of regulation of cell division, differentiation and aging of cells. The first objects of study were insects, helminths and other living organisms.
M. M. Zhelavskyi, S. P. Kernychnyi, O. Ya. Dmytriv   +2 more
doaj   +1 more source

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

International Journal of Molecular Sciences, 2019
Iron, the fourth most abundant element in the Earth’s crust, is vital in living organisms because of its diverse ligand-binding and electron-transfer properties.
N. Kajarabille, G. Latunde-Dada
semanticscholar   +1 more source