Results 251 to 260 of about 463,157 (297)

Resistance mechanisms to programmed cell death protein 1 and programmed death ligand 1 inhibitors

Expert Opinion on Biological Therapy, 2021
Introduction: In the past few years, administrating monoclonal humanized antibodies, namely checkpoint inhibitors, against programmed cell death protein 1 (PD-1), and its ligand (PD-L1), has yielded reassuring tumor regression rates. Anti-PD-1/PD-L1 checkpoint inhibitors disrupt the engagement of PD-1 on T-cells and their ligands on tumor or other ...
Parmida Sadat Pezeshki   +2 more
openaire   +2 more sources

Expression of programmed cell death ligand 1 and programmed cell death 1 in cutaneous warts

Journal of the American Academy of Dermatology, 2019
Cutaneous warts have high prevalence and cause significant morbidity. Understanding the mechanisms by which warts evade the immune system could lead to targeted and improved treatments.To determine whether cutaneous warts express programmed cell death ligand 1 (PD-L1) and to characterize the expression of programmed cell death 1 (PD-1) within the ...
Wesley Y, Yu   +4 more
openaire   +2 more sources

Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway

Journal of Medicinal Chemistry, 2018
The clinical success of inhibitors targeting the PD-1/PD-L1 pathway has made this an active field in cancer immunotherapy. Currently, most drugs targeting this pathway are monoclonal antibodies. Small-molecule inhibitors as the alternative to monoclonal antibodies are expected to overcome the disadvantages of mAbs which include production difficulties ...
Tianyu Wang   +6 more
openaire   +2 more sources

SAR study of small molecule inhibitors of the programmed cell death‐1/programmed cell death‐ligand 1 interaction

Chemical Biology & Drug Design, 2021
AbstractThe development of small molecule inhibitors of programmed cell death‐1/programmed cell death‐ligand 1 (PD‐1/PD‐L1) has drawn research interest for the treatment of cancer. Recently, we reported the discovery of a novel dimeric core small molecule PD‐1/PD‐L1 inhibitor.
Seiji Kawashita   +10 more
openaire   +2 more sources

Progress in programmed cell death-1/programmed cell death-ligand 1 pathway inhibitors and binding mode analysis

Molecular Diversity, 2022
Programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) plays an important role in negative regulating immunity. The search for effective PD-1/PD-L1 inhibitors has been at the cutting-edge of academic and industrial medicinal chemistry, leading to the emergence of 16 clinical candidate drugs and the launch of six ...
Xiaoyun Li   +4 more
openaire   +2 more sources

Programmed cell death-1 inhibition in lymphoma

The Lancet Oncology, 2015
Cancers can evade the host immune system by inducing upregulation of immune inhibitory signals. Anti-programmed cell death-1 (PD-1) monoclonal antibodies block these inhibitory signals allowing the host to mount an immune response against malignant cells.
Eliza A, Hawkes   +2 more
openaire   +2 more sources

Predictive Efficacy Biomarkers of Programmed Cell Death 1/Programmed Cell Death 1 Ligand Blockade Therapy

Recent Patents on Anti-Cancer Drug Discovery, 2016
Inhibitors of immune check-point molecule, programmed cell death 1 (PD-1) and its ligand, programmed cell death ligand 1 (PD-L1) have attracted much attention in cancer immunotherapy recently due to their durable antitumor effects in various malignances, especially the advanced ones. Unfortunately, only a fraction of patients with advanced tumors could
Xiao-Na, Fang, Li-Wu, Fu
openaire   +2 more sources

Home - About - Disclaimer - Privacy