Results 21 to 30 of about 463,157 (297)

A comparative study to assess the increased expression of programmed cell death-1 (PD1) and programmed cell death- ligand-1 (PDL1) in oral potentially malignant disorders and oral squamous cell carcinoma

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Programmed cell death-1 (PD-1) is expressed on the surface of activated T cells, while its ligand, PD-L1, is expressed on the surface of dendritic cells or macrophages. Objective: This study assessed the increased expression of PD-1 and PD-L1
Sonalika Srivastava, Abhishek Sinha, Sunita Srivastava, Anuj Mishra   +3 more
doaj   +1 more source

Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in Caenorhabditis elegans [PDF]

, 2012
Caspases are cysteine proteases that can drive apoptosis in metazoans and have critical functions in the elimination of cells during development, the maintenance of tissue homeostasis, and responses to cellular damage. Although a growing body of research
A Cauwels, A Degterev, A Gartner, A Raj, AH Wyllie, AM Chinnaiyan, B Conradt, B Pinan-Lucarre, B Schumacher, BT Hyman, D Xue, D Xue, Daniel P. Denning, DJ Dwyer, DJ Hoeppner, DP Denning, DT Harris, E Arama, E Pourkarimi, EC Andersen, EH Cheng, EM Hedgecock, ES Blum, F Chen, F Madeo, F Simmer, H. Robert Horvitz, HC Chang, Hermann Steller, HM Ellis, HT Schwartz, J Yuan, J Yuan, JE Sulston, JE Sulston, JF Kerr, JM Kinchen, JY Yuan, K Xu, M Darland-Ransom, MC Abraham, MC Abraham, MO Hengartner, MO Hengartner, NA Thornberry, PW Reddien, RA Lockshin, RE Ellis, S Brenner, S Harbinder, S Qi, S Seshagiri, S Shaham, S Shaham, S Shaham, SA Susin, T Hirose, TL Gumienny, V Venegas, VA Fadok, Victoria Hatch, X Geng, X Geng, X Wang, X Yang, Z Zhou   +65 more
core   +4 more sources

The incidence of pseudoprogressive disease associated with programmed cell death 1/programmed cell death ligand 1 inhibitors

Medicine, 2021
Abstract Background: The method to evaluate the efficacy of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors has become a big concern for researchers with its widely application. Pseudoprogressive disease (PPD) makes this process more difficult, which means that the tumor progressed at ...
Jingyi Zhang, Kexin Tan, Xuejiao Jiang, Shuyue Zheng, Jia Li, Chongxiang Xue, Xu Zhang, Huijuan Cui   +7 more
openaire   +2 more sources

Comprehensive insights into the effects and regulatory mechanisms of immune cells expressing programmed death-1/programmed death ligand 1 in solid tumors

Cancer Biology & Medicine, 2020
The programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) signaling pathway is an important mechanism in tumor immune escape, and expression of PD-L1 on tumor cells has been reported more frequently.
Min Liu, Qian Sun, Feng Wei, Xiubao Ren
doaj   +1 more source

Autophagy is activated and involved in cell death with participation of cathepsins during stress-induced microspore embryogenesis in barley [PDF]

, 2018
Microspores are reprogrammed towards embryogenesis by stress. Many microspores die after this stress, limiting the efficiency of microspore embryogenesis. Autophagy is a degradation pathway that plays critical roles in stress response and cell death.
Berenguer, Eduardo, Bárány, Ivett, Crespo González, José Luis, Pérez Pérez, Yolanda, Risueño, M. Carmen   +4 more
core   +1 more source

Catching up with solid tumor oncology: what is the evidence for a prognostic role of programmed cell death-ligand 1/programmed cell death-1 expression in B-cell lymphomas?

Haematologica, 2016
Therapeutic strategies targeting the programmed cell death-ligand 1/programmed cell death-1 pathway have shown significant responses and good tolerability in solid malignancies.
Fabienne McClanahan, Thomas G. Sharp, John G. Gribben   +2 more
doaj   +1 more source

PD-1/PD-L1 Correlates With the Efficacy of the Treatment of Concurrent Chemoradiotherapy in Cervical Cancer

Frontiers in Oncology, 2022
BackgroundCervical cancer (CC) is the third most common cancer worldwide, with high mortality rates. The programmed cell death 1 (PD-1)/(PD-1 ligand) PD-L1 has been reported to be an effective indicator in cancer development.
Hanqun Zhang, Shisheng Tan, Chunju Fang, Qi Zhang, Xue Cao, Yuncong Liu   +5 more
doaj   +1 more source

Efficacy of PD-1/PD-L1 inhibitors in advanced hepatocellular carcinoma: A systematic review and meta-analysis

Tzu Chi Medical Journal, 2023
Objectives: This study aimed to investigate the efficacy and safety of programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors in patients with advanced hepatocellular carcinoma (HCC).
Tzu-Rong Peng, Li-Jou Yang, Ta-Wei Wu
doaj   +1 more source

D-1 / PD-L1 EXPRESSION IN INVASIVE BREAST CARCINOMA / CANCER

Pakistan Armed Forces Medical Journal, 2021
Objective: To investigate the immunohistochemical expression of PD-1 and PD-L1 in breast cancer cases and its correlation with clinicopathological factors. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department,
Sammeen Salim, Muhammad Asif, Rabia Ahmed, Muhammad Tahir Khadim   +3 more
doaj   +1 more source

M2I-1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti-mitotic drugs via MCL-1s [PDF]

, 2019
Background Drugs such as taxanes, epothilones, and vinca alkaloids are widely used in the treatment of breast, ovarian, and lung cancers but come with major side effects such as neuropathy and loss of neutrophils and as single agents have a lack of ...
Dang, Nanmao, Gao, Fei, Huang, Dong, Huang, Jun-Yong, Jowsey, Paul, Li, Jianquan, Lightowlers, Robert N., Martinez-Lopez, Nuria   +7 more
core   +1 more source