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BMC Medicine, 2021 Background Chimeric antigen receptor T (CAR-T) cell therapy has limited effects in the treatment of solid tumors. Sulforaphane (SFN) is known to play an important role in inhibiting tumor growth, but its effect on CAR-T cells remains unclear. The goal of
Chunyi Shen +9 more
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The role of PD-1 signaling in health and immune-related diseases
Frontiers in Immunology, 2023 Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to mediate the mechanism of immune tolerance and provide immune homeostasis.
Ru-Yue Chen +10 more
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Gut Microbiota Modulates the Efficiency of Programmed Cell Death Protein 1 Cancer Immunotherapies
Iranian Journal of Allergy, Asthma and Immunology, 2022 Program cell death protein 1 (PD1) is considered as an inhibitory molecule that is expressed on the surface of activated T-cells and bound to PD-L1 and PD-L2 ligands.
Azam Samei, Mostafa Khedri
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Sultan Qaboos University Medical Journal, 2019 Programmed death ligand 1 (PD-L1) is an inhibitory molecule expressed by cancer cells to supress T-cell activity and escape anti-tumour immunity. The role of PD-L1 in cancer has been studied extensively as it is considered an important immune checkpoint ...
Malika Al-Dughaishi +5 more
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The prevalence of TNFα-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay.
PLoS ONE, 2011 Death receptor-induced programmed necrosis is regarded as a secondary death mechanism dominating only in cells that cannot properly induce caspase-dependent apoptosis.
Seda Çöl Arslan, Claus Scheidereit
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Pharmacology of Dostarlimab: A Review
Journal of Pharmaceutical Research, 2022 Dostarlimab is a humanised anti-PD-1 immunoglobulin (IgG4) monoclonal antibody (mAb). It has a high affinity for the PD-1 receptor and effectively inhibits interactions with PD-L1 and PD-L2 by blocking their binding to the PD-1 receptor ...
Arnab Roy, Akash Chaurasiya
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The Molecular Links between Cell Death and Inflammasome
Cells, 2019 Programmed cell death pathways and inflammasome activation pathways can be genetically and functionally separated. Inflammasomes are specialized protein complexes that process pro-inflammatory cytokines, interleukin-1β (IL-1β), and IL-18 to ...
Kwang-Ho Lee, Tae-Bong Kang
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Research Progress of Anti-PD-1/PD-L1 Therapy for Non-small Cell Lung Cancer with EGFR Mutation
Chinese Journal of Lung Cancer, 2022 The use of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) is the first line treatment for EGFR-mutant advanced non-small cell lung cancer (NSCLC), but drug resistance will be acquired within 1-2 years, and the following treatment
Yue ZHU, Zhaoxia DAI
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Predictive biomarkers of response to immune checkpoint inhibitors [PDF]
Farmacia Hospitalaria, 2020 Objective: The present paper provides a literature review aimed at identifying the tumor-dependent factors capable of influencing a subject’s response to immune checkpoint inhibitors, with a special emphasis on those that may act as predictive ...
María Sacramento Díaz-Carrasco +3 more
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Journal of Experimental Medicine, 2012 After encounter with its ligand, PD-1 translocates into TCR microclusters, where it transiently recruits SHP2 and suppresses phosphorylation of TCR signaling components and TCR-driven stop signals.
T. Yokosuka +5 more
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