Results 31 to 40 of about 174,697 (145)
BackgroundNatural Killer cells (NKs) represent the innate counterpart of TCRαβ lymphocytes and are characterized by a high anti-tumor and an anti-viral cytotoxic activity.
Marco Greppi +14 more
doaj +1 more source
Objective To investigate the expression of programmed cell death protein 1(PD-1), programmed cell death 1 ligand 1 (PD-L1) and tumor infiltrates lymphocytes (TIL) density in neuroblastoma and the relationship between them and the clinicopathological ...
QIAO Jiahua*, HAO Ziqi, HUANG Ye, WEI Junni, LI Suhong
doaj +1 more source
Diabetic ketoacidosis after treatment with pembrolizumab
Immune checkpoint inhibiting agents have been shown to precipitate type 1 diabetes. We report a case of acute severe diabetic ketoacidosis in a patient with no history of diabetes who developed ketoacidosis after starting anti-PD1 immunotherapy with ...
M. Hariz. F. Abdul Aziz +3 more
doaj +1 more source
Background A single‐agent of anti programmed cell death 1/programmed cell death ligand 1 (anti‐PD‐1/PD‐L1) therapy has been explored for resectable lung cancer before surgery.
Yuan Feng +20 more
doaj +1 more source
The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and programmed death receptor 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint inhibitors were landmarks in the treatment of non-small cell lung cancer (NSCLC ...
Xuefeng LENG, Jiandong MEI, Lunxu LIU
doaj +1 more source
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28 [PDF]
T-cell inhibitory receptors balance the activation signals provided by peptide/major histocompatibility complex and costimulatory receptors (1).
Leonardo, Chicaybam +1 more
openaire +2 more sources
Merkel cell carcinoma is a rare, aggressive skin cancer in which Merkel cell polyoma virus (MCPyV) is frequently pathogenically involved. After failure of anti-programmed cell death protein 1/programmed cell death ligand 1 immunotherapy, therapeutic ...
Ferdinand Toberer +8 more
doaj +1 more source
Regulation of Trypanosoma cruzi-Induced Myocarditis by Programmed Death Cell Receptor 1 [PDF]
ABSTRACTTrypanosoma cruziinfection causes intense myocarditis, leading to cardiomyopathy and severe cardiac dysfunction. Protective adaptive immunity depends on balanced signaling through a T cell receptor and coreceptors expressed on the T cell surface.
Fredy R S, Gutierrez +12 more
openaire +2 more sources
Immune checkpoint inhibitors have dramatically improved the prognosis of NSCLC. However, various immune-related adverse events (irAEs) have been reported. Cytokine release syndrome (CRS) is an irAE that is occasionally severe and life-threatening. CRS is
Ken Yamamoto, MD +3 more
doaj +1 more source
Programmed cell death-1 (PD-1) and its ligands, PD-L1 and PD-L2, have been regarded as important immune system regulatory molecules. The aberrant expression of the molecules has been related to several autoimmune disorders.
Mohammad Reza Javan +6 more
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