Results 71 to 80 of about 290,432 (308)

RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation. [PDF]

PLoS ONE, 2011
Programmed necrosis/necroptosis is an emerging form of cell death that plays important roles in mammalian development and the immune system. The pro-necrotic kinases in the receptor interacting protein (RIP) family are crucial mediators of programmed ...
YoungSik Cho, Thomas McQuade, Haibing Zhang, Jianke Zhang, Francis Ka-Ming Chan   +4 more
doaj   +1 more source

In situ and in silico kinetic analyses of programmed cell death-1 (PD-1) receptor, programmed cell death ligands, and B7-1 protein interaction network [PDF]

Journal of Biological Chemistry, 2017
Programmed cell death-1 (PD-1) is an inhibitory receptor with an essential role in maintaining peripheral tolerance and is among the most promising immunotherapeutic targets for treating cancer, autoimmunity, and infectious diseases. A complete understanding of the consequences of PD-1 engagement by its ligands, PD-L1 and PD-L2, and of PD-L1 binding to
Li, Kaitao, Cheng, Xiaoxiao, Tilevik, Andreas, Davis, Simon J., Zhu, Cheng   +4 more
openaire   +3 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Expression and clinical significance of PD-1, PD-L1 and tumor infiltrating lymphocytes in neuroblastoma

Zhongguo linchuang yanjiu
Objective To investigate the expression of programmed cell death protein 1(PD-1), programmed cell death 1 ligand 1 (PD-L1) and tumor infiltrates lymphocytes (TIL) density in neuroblastoma and the relationship between them and the clinicopathological ...
QIAO Jiahua*, HAO Ziqi, HUANG Ye, WEI Junni, LI Suhong
doaj   +1 more source

Diabetic ketoacidosis after treatment with pembrolizumab

Journal of Clinical and Translational Endocrinology Case Reports, 2017
Immune checkpoint inhibiting agents have been shown to precipitate type 1 diabetes. We report a case of acute severe diabetic ketoacidosis in a patient with no history of diabetes who developed ketoacidosis after starting anti-PD1 immunotherapy with ...
M. Hariz. F. Abdul Aziz, Isuru P. Fernando, Anjan Lenkanpally, Devaka J.S. Fernando   +3 more
doaj   +1 more source

Identification of a novel cord blood NK cell subpopulation expressing functional programmed death receptor-1

Frontiers in Immunology, 2023
BackgroundNatural Killer cells (NKs) represent the innate counterpart of TCRαβ lymphocytes and are characterized by a high anti-tumor and an anti-viral cytotoxic activity.
Marco Greppi, Valentina Obino, Rayan Goda, Federico Rebaudi, Simona Carlomagno, Simona Carlomagno, Mariella Della Chiesa, Simona Sivori, Simona Sivori, Gianluca Ubezio, Vanessa Agostini, Alessandra Bo, Silvia Pesce, Emanuela Marcenaro, Emanuela Marcenaro   +14 more
doaj   +1 more source

RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]

, 2017
Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P., Gale, Michael, Loo, Yueh-Ming, Martinez, Jennifer, Oberst, Andrew, Oguin III, Thomas H., Olsen, Tayla M., Orozco, Susana, Snyder, Annelise G., Tait, Stephen W.G.   +9 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Molecular Mechanism of Different Signaling Pathways in Regulating PD-L1 Expression in EGFR Mutated Lung Adenocarcinoma

Chinese Journal of Lung Cancer, 2018
The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and programmed death receptor 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint inhibitors were landmarks in the treatment of non-small cell lung cancer (NSCLC ...
Xuefeng LENG, Jiandong MEI, Lunxu LIU
doaj   +1 more source

Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]

, 2001
Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P, Lotto, RB, Price, DJ, Vali, L   +3 more
core   +1 more source