Results 81 to 90 of about 212,261 (297)

Differential Immunoexpression of Inhibitory Immune Checkpoint Molecules and Clinicopathological Correlates in Keratoacanthoma, Primary Cutaneous Squamous Cell Carcinoma and Metastases

Acta Dermato-Venereologica
Beyond established anti-programmed cell death protein 1/programmed cell death ligand 1 immunotherapy, T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain (TIGIT) and its ligand CD155 are promising novel ...
Anke S. Lonsdorf, Dominic Edelmann, Thomas Albrecht, Alexander Brobeil, Jannik Labrenz, Moritz Johanning, Richard F. Schlenk, Benjamin Goeppert, Alexander H. Enk, Ferdinand Toberer   +9 more
doaj   +1 more source

Expression of PD1 and PDL1 as immune-checkpoint inhibitors in mantle cell lymphoma

BMC Cancer, 2022
Background Mantle cell lymphoma (MCL) has remained incurable in most patients. The expression of PD-L1 as a prognostic and predictive marker has not been fully evaluated in MCL.
Fereshteh Ameli, Elham Shajareh, Maral Mokhtari, Farid Kosari   +3 more
doaj   +1 more source

Exceptional Response with Immunotherapy in a Patient with Anaplastic Thyroid Cancer [PDF]

, 2017
Chemotherapy with or without radiation is the standard therapy for anaplastic thyroid cancer (ATC), although the response rate is not high and not durable.
Babu, Sunil, Kiel, Patrick J., Kollipara, Revathi, Radovich, Milan, Schneider, Bryan   +4 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Multiple lung cancers including squamous cell carcinoma with strong PD-L1 expression and adenocarcinoma with EGFR exon 19 deletion: A case report

Respiratory Medicine Case Reports, 2020
We herein report a non-smoking 81-year-old man with advanced synchronous multiple primary lung cancers (SMPLC), containing squamous cell carcinoma with strong programmed death-ligand 1 expression in the middle lobe and adenocarcinoma with epidermal ...
Hirokazu Tokuyasu, Mika Horie, Soichiro Ishikawa, Hiromitsu Sakai, Hiroshi Miura, Akira Yamasaki   +5 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. [PDF]

, 2019
BACKGROUND:Programmed cell death ligand-1 (PD-L1) expression on tumor cells (TCs) is associated with improved survival in patients with head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy, although its role as a prognostic factor is ...
Baste, Neus, Clayburgh, Daniel, Cohen, Ezra EW, Fountzilas, George, Fujii, Takashi, Khaliq, Asud, Kim, Edward S, Lin, Derrick, Lipworth, Loren, Mehlhorn, Holger, Melillo, Giovanni, Pai, Sara I, Resteghini, Carlo, Shara, Nawar, Shire, Norah, Stokes, Michael, Twumasi-Ankrah, Philip, Wang, Huifen, Wildsmith, Sophie, Zhang, Jun   +19 more
core   +1 more source

Bcl-2 protein family: Implications in vascular apoptosis and atherosclerosis [PDF]

, 2006
Apoptosis has been recognized as a central component in the pathogenesis of atherosclerosis, in addition to the other human pathologies such as cancer and diabetes.
A Ashkenazi, A Bakhshi, A Basu, A Gross, A Letai, A Mandic, A Nechushtan, A Nechushtan, A Ruiz-Vela, A Saxena, A Schinzel, A Strasser, AE Rusinol, AJ Bruce-Keller, AP Gilmore, AS Belzacq, AZ Badrichani, B Antonsson, B Fadeel, B Hufnagel, C Adrain, C Borner, C Napoli, C Scaffidi, C Soldani, D de Moissac, D Decaudin, D Heiser, DE Wood, DG Kirsch, DJ Veis, DM Finucane, DW Dickson, E Oda, EA Slee, EH Cheng, EJ Ackermann, FA Sinicrope, G Basanez, G Molostvov, G van Loo, G van Loo, GD Norata, GJ Griffiths, GV Putcha, H He, H Kataoka, H Li, HH Kim, HS Lee, Huveyda Basaga, I Marzo, I Marzo, J Chen, J Han, J Liu, J Masuda, J Yang, J Yu, J Yu, J Zha, JC Reed, JL Bodmer, K Nakano, K Ochs, K Sakurai, K Wang, K Yamamoto, KM Hajra, KM Murphy, L He, M Aritomi, M del Mar Martinez-Senac, M Narita, M Nguyen, M Sata, M Sata, M Sattler, MB Bogdanov, MC Wei, MJ Pollman, MM Kockx, MR Bennett, MR Morissette, MR Sprick, MY Donath, N Donovan, N Mirkovic, N Motoyama, O Kutuk, O Meilhac, OW Rokhlin, Ozgur Kutuk, P Pauletto, PM Yao, Q Huang, R Rashmi, R Ross, R Ross, RA Gottlieb, RJ Alvarez, RM Kluck, S Conus, S Desagher, S Dramsi, S Grethe, S Krajewski, S Nouraini, S Ottilie, S Shimizu, S Takarada, S Vicca, S Vicca, SA Keogh, SA Memon, SC Ruffolo, SJ Korsmeyer, SJ Korsmeyer, SJ Neame, SL Schendel, SN Willis, SR Datta, SR Datta, SW Muchmore, SY Hsu, T Ito, T Lee, T Shibue, TD Littlewood, TS Soderstrom, UK Messmer, V Mikhailov, V Mikhailov, V Petronilli, V Petronilli, W Zhang, X Cao, XM Sun, Y Deng, Y Gazitt, Y Konishi, Y Liang, Y Michowitz   +142 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Prognostic value of PD-L1 expression on tumor cells combined with CD8+ TIL density in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy. [PDF]

, 2020
BACKGROUND/AIM:mmune checkpoint inhibition (CPI) has an increasing impact in the multimodal treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Increasing evidence suggests treatment outcome depending on tumor cell PD-L1 expression.
Belka, Claus, Eze, Chukwuka, Gennen, Kathrin, Karin, Monika, Käsmann, Lukas, Manapov, Farkhad, Neumann, Jens, Orth, Michael, Reu, Simone, Roengvoraphoj, Olarn, Taugner, Julian, Tufman, Amanda   +11 more
core   +1 more source