Results 41 to 50 of about 542,975 (311)

A Real-World Study on the Effectiveness and Safety of Pembrolizumab Plus Chemotherapy for Nonsquamous NSCLC

JTO Clinical and Research Reports, 2022
Introduction: The real-world effectiveness of combination treatment with cytotoxic chemotherapy and programmed cell death protein-1 or programmed death-ligand 1 inhibitor for NSCLC, especially for the elderly (aged ≥75 y) or those with poor performance ...
Daichi Fujimoto, MD, Satoru Miura, MD, PhD, Kenichi Yoshimura, MD, PhD, Kazushige Wakuda, MD, Yuko Oya, MD, Koji Haratani, MD, PhD, Shoichi Itoh, MD, Takehiro Uemura, MD, PhD, Ryotaro Morinaga, MD, PhD, Takayuki Takahama, MD, PhD, Kazuhisa Nakashima, MD, Motoko Tachihara, MD, PhD, Go Saito, MD, Junko Tanizaki, MD, PhD, Kohei Otsubo, MD, PhD, Satoshi Ikeda, MD, Hirotaka Matsumoto, MD, Satoshi Hara, MD, Akito Hata, MD, Takeshi Masuda, MD, PhD, Nobuyuki Yamamoto, MD, PhD   +20 more
doaj   +1 more source

Differential Requirement for CD70 and CD80/CD86 in Dendritic Cellmediated Activation of Tumor Tolerized CD8 T Cells [PDF]

, 2012
A major obstacle to efficacious T cell-based cancer immunotherapy is the tolerizing-tumor microenvironment that rapidly inactivates tumor-infiltrating lymphocytes.
Bai, Ailin, Bak, Peter, Barnkob, Mike Stein, Chen, Jianzhu, Higham, Eileen M., Wittrup, Karl Dane   +5 more
core   +1 more source

Expression patterns of programmed death-1 and programmed death-1 ligand-1 on T cells in gastric cancer.

Oncology letters, 2019
The aim of the present study was to evaluate programmed death-1 (PD-1) and programmed death-1 ligand-1 (PD-L1) expression in gastric carcinoma and to assess their effect on survival rate. A total of 170 surgically resected specimens were obtained from patients diagnosed with gastric carcinoma at St.
Kim, Ji-Hyun, Kim, Shinn-Young, Shin, Eun-Young, Jung, Ji-Han, Choi, Hyun-Joo, Jun, Kyong-Hwa   +5 more
openaire   +2 more sources

Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients [PDF]

, 2014
Rationale: There is mounting evidence of a higher incidence of coronary heart disease (CHD) in cytomegalovirus (CMV) seropositive individuals. Objective: The aim of this study was to investigate whether acute MI triggers an inflammatory T-cell ...
Bagnall, Alan, Boag, Stephen, Das, Rajiv, Dimmick, Ian, Egred, Mohaned, Fiser, Karel, Hoffmann, Jedrzej, Keavney, Bernard, Martin-Ruiz, Carmen, Murali, Santosh, Pircher, Hanspeter, Shmeleva, Evgeniya, Spyridopoulos, Ioakim, Todryk, Stephen, von Zglinicki, Thomas   +14 more
core   +1 more source

Diversification of a protein kinase cascade: IME-2 is involved in nonself recognition and programmed cell death in Neurospora crassa. [PDF]

, 2012
Kinase cascades and the modification of proteins by phosphorylation are major mechanisms for cell signaling and communication, and evolution of these signaling pathways can contribute to new developmental or environmental response pathways.
Bueche, Joanna A, Glass, N Louise, Hutchison, Elizabeth A   +2 more
core   +2 more sources

Comparison of Immune Checkpoint Molecules PD-1 and PD-L1 in Paired Primary and Recurrent Glioma: Increasing Trend When Recurrence

Brain Sciences, 2022
Purpose: This study aims to investigate PD-1/PD-L1 expression patterns in paired primary and recurrent gliomas. Methods: From January 2008 to December 2014, 42 patients who underwent surgical resections of primary and recurrent gliomas were ...
Wei Yu, Anwen Shao, Xiaoqiu Ren, Zexin Chen, Jinghong Xu, Qichun Wei   +5 more
doaj   +1 more source

The expression of programmed death 1 in tumor-infiltrating lymphocytes of hepatocellular carcinoma and its correlation with prognosis

Zhongguo aizheng zazhi, 2021
Background and purpose: Programmed death 1 (PD-1) plays an important role in the regulation of peripheral immune tolerance. The expression of PD-1 in tumor-infiltrating lymphocytes of hepatocellular carcinoma (HCC) and the relationship between PD-1 ...
肖　锋, 肖静文, 邵建国, 陈丽燕, 顾春燕   +4 more
doaj  

Targeting PD-1/PD-L1 inhibits rejection in a heterotopic tracheal allograft model of lung transplantation

Frontiers in Pharmacology, 2023
Immune checkpoint molecules such as programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) have revolutionized the field of lung cancer treatment.
Taisuke Kaiho, Hidemi Suzuki, Atsushi Hata, Hiroki Matsumoto, Kazuhisa Tanaka, Yuichi Sakairi, Shinichiro Motohashi, Shinichiro Motohashi, Ichiro Yoshino   +8 more
doaj   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells [PDF]

, 2018
CD4+ T cell differentiation into multiple T helper (Th) cell lineages is critical for optimal adaptive immune responses. This report identifies an intrinsic mechanism by which programmed death-1 receptor (PD-1) signaling imparted regulatory phenotype to ...
Amarnath, Shoba, Berlinguer-Palmini, Rolando, Bogyo, Matthew, Eckhaus, Michael A., Edgington-Mitchell, Laura, Felizardo, Tania C., Flomerfelt, Francis A., Fowler, Daniel H., Gangaplara, Arunakumar, Knight, David, Laurence, Arian, Liniany, Lukasz P., Mallett, Grace, Martinez-Fabregas, Jonathan, Samsel, Leigh A., Shevach, Ethan M., Stathopoulou, Chaido, van Kasteren, Sander I., Watts, Colin, Yim, Joshua J., Zhu, Jinfang   +20 more
core   +2 more sources