Results 41 to 50 of about 380,452 (284)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
ScaFi: A Scala DSL and Toolkit for Aggregate Programming
SoftwareX, 2022 Supported by current socio-scientific trends, programming the global behaviour of whole computational collectives makes for great opportunities, but also significant challenges.
Roberto Casadei +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Use of Reactive Programming in the Proposed Model for Cloud Security Controlled by ITSS
Computers, 2022 Reactive programming is a popular paradigm that has been used as a new solution in our proposed model for security in the cloud. In this context, we have been able to reduce the execution time compared to our previous work for the model proposed in cloud
Dhuratë Hyseni +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
A multi-paradigm approach for mobile agents development
Journal of Computer Science and Technology, 2001 Mobile agent systems have received important attention in the last years as a new programming paradigm for widely distributed and heterogeneous systems.
Edgardo A. Belloni
doaj
Graphical Flow-based Spark Programming
Journal of Big Data, 2020 Increased sensing data in the context of the Internet of Things (IoT) necessitates data analytics. It is challenging to write applications for Big Data systems due to complex, highly parallel software frameworks and systems.
Tanmaya Mahapatra, Christian Prehofer
doaj +1 more source
The paradigms of programming [PDF]
Communications of the ACM, 1979 Today I want to talk about the paradigms of programming, how they affect our success as designers of computer programs, how they should be taught, and how they should be embodied in our programming languages.
openaire +2 more sources