Results 51 to 60 of about 1,673,196 (291)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Plaque progression: Where, why, and how fast? A review of what we have learned from the analysis of patient data from the PARADIGM registry

, 2022
Ischemic heart disease is the most common cause of mortality worldwide. The pathophysiology of myocardial infarction relates to temporal changes of atherosclerotic plaque culminating in plaque rupture, erosion or hemorrhage and the subsequent thrombotic ...
Indraratna, P., Khasanova, E., Narula, J., PARADIGM Investigators, Chang, H.J., Bax, J.J., Shaw, L.J., Tzimas, G., Lin, F.Y., Leipsic, J., Gulsin, G.S., Park, K.H., Takagi, H., Lee, S.E.   +13 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Domain-independent programming by demonstration in existing applications [PDF]

, 2001
This paper describes Familiar, a domain- independent programming by demonstration system for automating iterative tasks in existing, unmodified applications on a popular commercial platform.
Paynter, Gordon W., Gordon W. Paynter, Ian H. Witten, Witten, Ian H.   +3 more
core   +1 more source

Low-Code Mixed Reality Programming Framework for Collaborative Robots: From Operator Intent to Executable Trajectories

Robotics
Efficient and intuitive programming strategies are essential for enabling robots to adapt to small-batch, high-mix production scenarios. Mixed reality (MR) and programming by demonstration (PbD) have shown great potential to lower the programming barrier
Ziyang Wang, Zhihai Li, Hongpeng Yu, Duotao Pan, Songjie Peng, Shenlin Liu   +5 more
doaj   +1 more source

Unia Europejska jako społeczność ludów dobrze urządzonych? Obiektowa interpretacja prawa ludów Johna Rawlsa – przyczynek do przyszłych badań [PDF]

Archiwum Filozofii Prawa i Filozofii Społecznej
This article aims to present an interpretative perspective on the concept of the law of peoples, enabling its contemporary conceptualization. According to the main research thesis of the article, the concepts of the object-oriented programming paradigm ...
Michał Kordziński
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Foundations of Total Functional Data-Flow Programming [PDF]

Electronic Proceedings in Theoretical Computer Science, 2014
The field of declarative stream programming (discrete time, clocked synchronous, modular, data-centric) is divided between the data-flow graph paradigm favored by domain experts, and the functional reactive paradigm favored by academics.
Baltasar Trancón y Widemann, Markus Lepper   +1 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source