Results 61 to 70 of about 1,673,196 (291)
A Parallel Plug-In Programming Paradigm [PDF]
, 2006 Software component architectures allow assembly of applications from individual software modules based on clearly defined programming interfaces, thus improving the reuse of existing solutions and simplifying application development. Furthermore, the plug-in programming paradigm additionally enables runtime reconfigurability, making it possible to ...
Ronald Baumann +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
ScaFi: A Scala DSL and Toolkit for Aggregate Programming
SoftwareX, 2022 Supported by current socio-scientific trends, programming the global behaviour of whole computational collectives makes for great opportunities, but also significant challenges.
Roberto Casadei +3 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Concepts and Paradigms for Neuromorphic Programming
CoRR, 2023 The value of neuromorphic computers depends crucially on our ability to program them for relevant tasks. Currently, neuromorphic computers are mostly limited to machine learning methods adapted from deep learning. However, neuromorphic computers have potential far beyond deep learning if we can only make use of their computational properties to harness
openaire +3 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A multi-paradigm approach for mobile agents development
Journal of Computer Science and Technology, 2001 Mobile agent systems have received important attention in the last years as a new programming paradigm for widely distributed and heterogeneous systems.
Edgardo A. Belloni
doaj
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Graphical Flow-based Spark Programming
Journal of Big Data, 2020 Increased sensing data in the context of the Internet of Things (IoT) necessitates data analytics. It is challenging to write applications for Big Data systems due to complex, highly parallel software frameworks and systems.
Tanmaya Mahapatra, Christian Prehofer
doaj +1 more source