Results 61 to 70 of about 37,638 (261)
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Le Matematiche, 1988 This paper describes a SETL interpreter written in SETL. This module may be reused as a basis to build debuggers, type checkers, symbolic executers, tracers, and many other general purpose programming tools. Other more advanced uses include experimenting
D. Aliffi +3 more
doaj
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Going beyond BDI for agent-based simulation
Journal of Information and Telecommunication, 2019 Research in multi-agent systems has resulted in agent programming languages and logics that are used as a foundation for engineering multi-agent systems.
John Bruntse Larsen
doaj +1 more source
Preliminary Evidence to Support a De-Escalated Cochlear Implant Programming Paradigm for New Adult Recipients: A Systematic Review. [PDF]
J Clin Med, 2023 Dornhoffer JR +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Logic programming extensions of Horn clause logic
Le Matematiche, 1988 Logic programming is now firmly established as an alternative programming paradigm, distinct and arguably superior to the still dominant imperative style of, for instance, the Algol family of languages.
Ron Sigal
doaj
Practical Benefits of Aspect-Oriented Programming Paradigm in Discrete Event Simulation
Modelling and Simulation in Engineering, 2014 Aspect-oriented modeling and simulation is a new approach which uses the separation of concerns principle to enhance the quality of models and simulation tools. It adopts the separation of concerns (SOC) principle.
Meriem Chibani +2 more
doaj +1 more source