Results 221 to 230 of about 9,033,749 (289)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Exploring the Perspectives of Different Professions on Task-Based Upper-Limb Prosthesis Assessment Techniques. [PDF]

J Multidiscip Healthc
Siegel JR, Gavrilov MG, Roberts A, Waraich SA, Whittle RS, Schofield JS.   +5 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Gender Differences in Medical Students' Self-Assessment: Longitudinal Multi-Cohort Study. [PDF]

JMIR Med Educ
Handke L, Friederichs H.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A Lightweight Vision-Language-Action Policy with Progress-Aware Hybrid Execution for UAV Waypoint Navigation in AirSim. [PDF]

Sensors (Basel)
Xu Y, Lin H, Yang Y, Xia J, Han Z.
europepmc   +1 more source

Implementing pharmacogenetic-guided prescribing in general practice: a qualitative process evaluation. [PDF]

Implement Sci Commun
Brunton L, Newman W, McDermott J, Wilson P.   +3 more
europepmc   +1 more source

DEMATEL-based gamified instructional design for music teacher education. [PDF]

Front Psychol
Chen C, Ahmad Rashid RB, Xue L.
europepmc   +1 more source

Qualitative Study of Healthcare Providers and Test Recipients on Progress and Implementation Gaps in HIV Testing Strategies - Five Regions, China, November 2023-July 2024. [PDF]

China CDC Wkly
Shi L, Zhang Y, Han L, Jiang H, Fu X, Zheng M, Duan S, He N, Ding Y.   +8 more
europepmc   +1 more source

Cost-effectiveness of virtual patient integration in dermatology education: evidence for precision education by learner expertise. [PDF]

BMC Med Educ
Hung CT, Liu SW, Wu SE, Liu FC.
europepmc   +1 more source