Results 1 to 10 of about 5,027,565 (330)

Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both?

Frontiers in Immunology, 2023
Cytotoxic lymphocytes (CLs), specifically cytotoxic T lymphocytes and natural killer cells, are indispensable guardians of the immune system and orchestrate the recognition and elimination of cancer cells. Upon encountering a cancer cell, CLs establish a
Elena Ockfen, Elena Ockfen, Liza Filali, Diogo Pereira Fernandes, Diogo Pereira Fernandes, Céline Hoffmann, Clément Thomas   +6 more
doaj   +1 more source

Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus

Frontiers in Cell and Developmental Biology, 2023
The actin cytoskeleton plays a critical role in cancer cell invasion and metastasis; however, the coordination of its multiple functions remains unclear. Actin dynamics in the cytoplasm control the formation of invadopodia, which are membrane protrusions
Takouhie Mgrditchian, Joshua Brown-Clay, Céline Hoffmann, Tanja Müller, Liza Filali, Elena Ockfen, Xianqing Mao, Flora Moreau, Carla Pou Casellas, Tony Kaoma, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Michel Mittelbronn, Clément Thomas   +16 more
doaj   +1 more source

A Mammary Organoid Model to Study Branching Morphogenesis

Frontiers in Physiology, 2022
Branching morphogenesis is the process that gives rise to branched structures in several organs, such as the lung, the kidney, and the mammary gland. Although morphologically well described, the exact mechanisms driving branch elongation and bifurcation ...
Marika Caruso, Sjanie Huang, Larissa Mourao, Larissa Mourao, Colinda L. G. J. Scheele, Colinda L. G. J. Scheele   +5 more
doaj   +1 more source

The impact of phenotype, ethnicity and genotype on progression of Type 2 diabetes mellitus [PDF]

, 2020
Aim: To conduct a comprehensive review of studies of glycaemic deterioration in type 2 diabetes and identify the major factors influencing progression.Methods: We conducted a systematic literature search with terms linked to type 2 diabetes progression ...
Anjana, Ranjit M., Dawed, Adem Y., Donnelly, Louise A., Gan, Sushrima, Mohan, Viswanathan, Palmer, Colin, Pearson, Ewan, Thakarakkattil Narayanan Nair, Anand   +7 more
core   +2 more sources

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

Frontiers in Immunology, 2020
Neutrophil Extracellular Traps (NETs) are net-like structures composed of DNA-histone complexes and proteins released by activated neutrophils. In addition to their key role in the neutrophil innate immune response, NETs are also involved in autoimmune ...
Maria Teresa Masucci, Michele Minopoli, Silvana Del Vecchio, Maria Vincenza Carriero   +3 more
doaj   +1 more source

A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies

Cells, 2022
Cancer stem cells play a crucial role in tumor initiation, metastasis, and resistance to treatment. Cellular heterogeneity and plasticity complicate the isolation of cancer stem cells.
Céline Hervieu, Mireille Verdier, Elodie Barthout, Gaëlle Bégaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet   +8 more
doaj   +1 more source

Detection of Glycosylated Markers From Cancer Stem Cells With ColoSTEM Dx Kit for Earlier Prediction of Colon Cancer Aggressiveness

Frontiers in Oncology, 2022
Nowadays, colon cancer prognosis still difficult to predict, especially in the early stages. Recurrences remain elevated, even in the early stages after curative surgery.
Sabrina Blondy, Stéphanie Durand, Aurélie Lacroix, Niki Christou, Niki Christou, Charline Bouchaud, Maud Peyny, Serge Battu, Serge Battu, Alain Chauvanel, Alain Chauvanel, Vincent Carré, Marie-Odile Jauberteau, Marie-Odile Jauberteau, Fabrice Lalloué, Muriel Mathonnet, Muriel Mathonnet   +16 more
doaj   +1 more source

Higher Incidence of B Cell Malignancies in Primary Immunodeficiencies: A Combination of Intrinsic Genomic Instability and Exocytosis Defects at the Immunological Synapse

Frontiers in Immunology, 2020
Congenital defects of the immune system called primary immunodeficiency disorders (PID) describe a group of diseases characterized by a decrease, an absence, or a malfunction of at least one part of the immune system.
Jérôme Mastio, Mezida B. Saeed, Hannah Wurzer, Max Krecke, Lisa S. Westerberg, Clément Thomas   +5 more
doaj   +1 more source

Comparison of the Illumina NextSeq 2000 and GeneMind Genolab M sequencing platforms for spatial transcriptomics

BMC Genomics, 2023
Background The Illumina sequencing systems demonstrate high efficiency and power and remain the most popular platforms. Platforms with similar throughput and quality profiles but lower costs are under intensive development. In this study, we compared two
Iamshchikov Pavel, Larionova Irina, Gerashchenko Tatiana, Piankov Denis, Koshkin Philipp, Korostelev Sergei, Denisov Evgeny   +6 more
doaj   +1 more source

RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity

BMC Cancer, 2023
Background Endocrine-resistant breast cancers have elevated expression of XBP1, where it drives endocrine resistance by controlling the expression of its target genes.
David Barua, Afrin Sultana, Md Nahidul Islam, Fergus Cox, Ananya Gupta, Sanjeev Gupta   +5 more
doaj   +1 more source