Results 91 to 100 of about 6,463,095 (311)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Progression-free survival with successive suppression and reintroduction of the studies, one-by-one (jackknife).

, 2019
Progression-free survival with successive suppression and reintroduction of the studies, one-by-one (jackknife).
Giuseppe Luigi Banna (6593093), Jean-Pierre Daurès (7288886), Jean-Louis Pujol (748145), Aude Guillou (7288883), Manlio Mencoboni (7288874), Amandine Coffy (5570636), Andrea Camerini (7288871), Epaminontas Samantas (53834), Milena Gusella (735350), Athanasios Kotsakis (74454), Aldo Pezzuto (7288877), Felice Pasini (735351), Benoît Roch (5285813), Cemil Bilir (7288880), Fabrice Barlesi (5653306)   +14 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Long-term outcomes and prognostic factors after surgery alone for brain arteriovenous malformation

Brain Circulation
OBJECTIVES: There is a paucity of data regarding the long-term hemorrhage/progression outcomes of brain arteriovenous malformation (BAVM). The purpose of this study was to examine the outcomes of surgical treatment alone over a long follow-up period ...
Zhao-Ying Zhu, Wei Zhang, Li-Chuan Gao, Gui-Jun Zhang, Jing Chen   +4 more
doaj   +1 more source

Multivariate analysis, overall & progression-free survival.

, 2022
Multivariate analysis, overall & progression-free survival.
Nina Jehanno (11949663), Pierre Payoux (3484706), Daniel Orbach (11949669), Marie-Pierre Castex (11949666), Thomas Mognetti (582844), Corradini Nadège (11949672), Helio Fayolle (11949660), Anne Hitzel (11949675), Valerie Lauwers-Cances (437048)   +8 more
core   +1 more source

Radiographic Progression-Free Survival and Clinical Progression-Free Survival as Potential Surrogates for Overall Survival in Men With Metastatic Hormone-Sensitive Prostate Cancer

Journal of Clinical Oncology
PURPOSE Despite major increases in the longevity of men with metastatic hormone-sensitive prostate cancer (mHSPC), most men still die of prostate cancer. Phase III trials assessing new therapies in mHSPC with overall survival (OS) as the primary end point will take approximately a decade to complete.
Susan Halabi, Akash Roy, Larysa Rydzewska, Siyuan Guo, Peter Godolphin, Maha Hussain, Catherine Tangen, Ian Thompson, Wanling Xie, Michael A. Carducci, Matthew R. Smith, Michael J. Morris, Gwenaelle Gravis, David P. Dearnaley, Paul Verhagen, Takayuki Goto, Nick James, Marc E. Buyse, Jayne F. Tierney, Christopher Sweeney   +19 more
openaire   +3 more sources

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Pre-Existing Diabetes Limits Survival Rate After Immune Checkpoint Inhibitor Treatment for Advanced Lung Cancer: A Retrospective Study in Japan

Diabetes, Metabolic Syndrome and Obesity, 2021
Kaori Hisanaga,1 Hiroshi Uchino,1 Naoko Kakisu,1 Masahiko Miyagi,1 Fukumi Yoshikawa,1 Genki Sato,1 Kazutoshi Isobe,2 Kazuma Kishi,2 Sakae Homma,3 Takahisa Hirose1 1Division of Diabetes, Metabolism and Endocrinology, Department of Medicine, Toho ...
Hisanaga K, Uchino H, Kakisu N, Miyagi M, Yoshikawa F, Sato G, Isobe K, Kishi K, Homma S, Hirose T   +9 more
doaj  

Overall survival, progression free survival and event free survival for all patients.

, 2013
Overall survival, progression free survival and event free survival for all patients.
Andrew Cooke (418925), Shahida Ahmed (418924), Morel Rubinger (418921), Timothy E. Owen (418920), Naseer Ahmed (418919), Zoann Nugent (418923), Gaynor Williams (418922)   +6 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source