Results 131 to 140 of about 701,268 (244)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Clinical and Survival Insights into Carcinoma Penis: A Retrospective Analysis at a Tertiary Care Facility

South Asian Journal of Cancer
Santosh Kumar Swain, Lalatendu Moharana, Ghanashyam Biswas, Lipsita Samantaray, Ayush Dubey, Reetu Singhal, Bhavya Inimerla, Antara Sanyal, Swati Sucharita Mohanty, Soumya Surath Panda   +9 more
doaj   +1 more source

MYO18A Expression is a Prognostic Factor for Progression-Free Survival in Grade 4 Adult gliomas. Preliminary Report. [PDF]

Oncol Res
Strąk A, Grzybowska-Szatkowska L, Cisek P, Ostrowska-Leśko M, Dudka J, Kubik J, Osuchowski J, Szmygin P, Jarosz B, Krajka A, Krajka T, Szatkowski K, Ślaska B.   +12 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Automated Pretreatment Thoracic CT-Based Body Composition Analysis Predicts Progression-Free Survival in Head and Neck Cancer. [PDF]

J Clin Med
Jungbauer F, Arndt C, Huber L, Lammert A, Rotter N, Scherl C, Seiz E, Vahidi Noghani F, Schoenberg SO, Haubold J, Ludwig S, Affolter A, Tollens F, Nörenberg D, Ludwig JM.   +14 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A comparative study of strategies for spinal casting in early onset scoliosis : five-year progression-free survival analysis. [PDF]

Bone Jt Open
Dermott JA, Kim DJ, Switzer LS, Nadler EB, Camp MW, Lebel DE.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The usefulness of progression-free survival in surgical treatment of lung metastases

Polish Journal of Thoracic and Cardiovascular Surgery, 2022
Jarosław Religioni, Daniel Rabczenko, Tadeusz Orłowski   +2 more
doaj   +1 more source

Progression-Free Survival with PARP Inhibitors According to Clinical Risk in Patients with Ovarian Cancer: An Indirect Comparison Using Reconstructed Data. [PDF]

Oncol Res
Gasperoni L, Del Bono L, Farolfi A, Messori A, Damuzzo V.   +4 more
europepmc   +1 more source