Mathematical modelling of cancer invasion: Phenotypic transitioning provides insight into multifocal foci formation [PDF]
arXiv, 2023 The transition from the epithelial to mesenchymal phenotype and its reverse (from mesenchymal to epithelial) are crucial processes necessary for the progression and spread of cancer. In this paper, we investigate how phenotypic switching at the cancer cell level impacts on behaviour at the tissue level, specifically on the emergence of isolated foci of
arxiv
Progressive multifocal leukoencephalopathy: new concepts
Arquivos de Neuro-Psiquiatria, 2013 Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS caused by reactivation of JC virus (JCV) in a setting of cellular immunosuppression.
Marco A. Lima
doaj +1 more source
JC virus-DNA detection is associated with CD8 fffector accumulation in peripheral blood of patients with multiple sclerosis under natalizumab treatment, independently from JC virus serostatus [PDF]
, 2018 Although natalizumab (anti-α4 integrin) represents an effective therapy for relapsing remitting multiple sclerosis (RRMS), it is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus ...
Anzivino, Elena +16 more
core +3 more sources
Progressive multifocal leukoencephalopathy: rheumatological aspects
Современная ревматология, 2015 Progressive multifocal leukoencephalopathy (PML) is a severe progressive viral disease that affects the central nervous system in patients with immunodeficiency.
Boris Sergeevich Belov
doaj +1 more source
Myoclonus as an unusual presentation of progressive multifocal leukoencephalopathy in a HIV positive patient [PDF]
Romanian Journal of Neurology, 2012 From mild muscular contractions to gross jerks affecting the whole body, myoclonus is an involuntary movement caused by an excessive discharge from a group of neurons located in one or multiple sites from cortical to peripheral level.
Lucian Chicea +4 more
doaj +1 more source
Smoldering myeloma presenting as progressive multifocal leukoencephalopathy: a case report
Journal of Medical Case Reports, 2012 Introduction Progressive multifocal leukoencephalopathy is an opportunistic infection occurring in patients with severe cellular immunodeficiency. This case highlights the role of cellular immunodeficiency in the reactivation of John Cunningham virus in ...
Troppmann Martina +3 more
doaj +1 more source
Latent Space Analysis of VAE and Intro-VAE applied to 3-dimensional MR Brain Volumes of Multiple Sclerosis, Leukoencephalopathy, and Healthy Patients [PDF]
arXiv, 2021 Multiple Sclerosis (MS) and microvascular leukoencephalopathy are two distinct neurological conditions, the first caused by focal autoimmune inflammation in the central nervous system, the second caused by chronic white matter damage from atherosclerotic microvascular disease.
arxiv
Progressive multifocal leukoencephalopathy after fingolimod treatment
Neurology, 2018 Objective We describe the characteristics of the 15 patients with fingolimod-associated progressive multifocal leukoencephalopathy (PML) identified from the Novartis data safety base and provide risk estimates for the disorder.
J. Berger +6 more
semanticscholar +1 more source
Multifocal diffractive lens generating several fixed foci at different design wavelengths [PDF]
Opt. Express 26, 4698-4709 (2018), 2018 We propose a method for designing multifocal diffractive lenses generating prescribed sets of foci with fixed positions at several different wavelengths. The method is based on minimizing the difference between the complex amplitudes of the beams generated by the lens microrelief at the design wavelengths, and the functions of complex transmission of ...
arxiv +1 more source
Allogeneic BK Virus–Specific T Cells for Progressive Multifocal Leukoencephalopathy
New England Journal of Medicine, 2018 &NA; JC virus, the cause of progressive multifocal leukoencephalopathy (PML), and the BK virus are genetically similar and share sequence homology in immunogenic proteins.
M. Muftuoglu +12 more
semanticscholar +1 more source