Results 61 to 70 of about 20,462 (241)

A clinical approach to the diagnosis of patients with leukodystrophies and genetic leukoencephelopathies [PDF]

open access: yes, 2014
Leukodystrophies (LD) and genetic leukoencephalopathies (gLE) are disorders that result in white matter abnormalities in the central nervous system (CNS).
Bernard, Geneviève   +14 more
core   +2 more sources

Tafasitamab as Monotherapy or in Combination in Japanese Patients With B‐Cell Non‐Hodgkin Lymphoma: Results From the Phase 1b J‐MIND Study

open access: yesCancer Science, EarlyView.
J‐MIND evaluated the safety and tolerability of tafasitamab, a CD19‐targeting monoclonal antibody, alone or in combination with other therapies in Japanese patients with B‐cell non‐Hodgkin lymphoma (NHL). Most common treatment‐emergent adverse events across all groups were hematological, and no serious tafasitamab treatment‐related or fatal adverse ...
Koji Izutsu   +7 more
wiley   +1 more source

Adverse reactions of biological therapies in patients with psoriasis [PDF]

open access: yes, 2017
Psoriasis is a chronic, immune-mediated disorder characterized by well demarcated, erythematous plaques covered by thick, silvery-white scales, most often located on the knees, elbows, sacral area and scalp.
Georgescu, Simona R.   +5 more
core   +4 more sources

Stewardship of Molecular Diagnostics in Transplant Viral Infections

open access: yesTransplant Infectious Disease, EarlyView.
ABSTRACT The transplant environment requires special considerations when testing for viral infections as immunosuppression results in atypical infection profiles. Microbes otherwise considered commensals or causing mild disease can lead to severe infections in transplant environments. Therefore, guidelines tend to recommend broader microbial testing in
Scott Sugden   +3 more
wiley   +1 more source

Cerebellar Progressive Multifocal Leukoencephalopathy Mimicking Anti-Yo-Antibody-Associated Rapidly Progressive Cerebellar Syndrome

open access: yesNeurology International, 2023
A 58-year-old woman with a history of systemic lupus erythematosus (SLE) who was taking prednisolone and mycophenolate mofetil presented with gait disturbances that progressively worsened over a period of 3 months. Her blood test and cerebrospinal fluid (
Takayoshi Akimoto   +4 more
doaj   +1 more source

Six‐Year Trends in Real‐World Data Use for Post‐Marketing Surveillance of New Medical Products in Japan

open access: yesClinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami   +2 more
wiley   +1 more source

Progressive multifocal leukoencephalopathy in a child with acquired immunodeficiency syndrome (AIDS) Leucoencefalopatia multifocal progressiva em uma criança com síndrome da imunodeficiênda adquirida

open access: yesArquivos de Neuro-Psiquiatria, 1997
Progressive multifocal leukoencephalopathy is a rare viral-induced demyelinating disease associated to immunodeficiency. A 10-year-old boy with AIDS is reported, who developed subacute cerebellar signs and symptoms with multiple cranial nerve involvement
Alexandra Prufer de Q.C. Araujo   +5 more
doaj   +1 more source

Spectrum of Neurologic Complications in Chronic Lymphocytic Leukemia [PDF]

open access: yes, 2012
Neurologic disease is believed to be an unusual complication during the course of chronic lymphocytic leukemia. Nevertheless, it has already been proven in autopsy series that the incidence of occult nervous system infiltration is much higher than was ...
Lopes Silva, R
core   +1 more source

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

open access: yesAnnals of Clinical and Translational Neurology, Volume 13, Issue 1, Page 85-96, January 2026.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich   +10 more
wiley   +1 more source

Safety and Effectiveness of Dimethyl Fumarate in Japanese Patients With Multiple Sclerosis: 2‐Year Post‐Marketing Surveillance Data

open access: yesNeurology and Clinical Neuroscience, Volume 14, Issue 1, Page 54-68, January 2026.
ABSTRACT Background Dimethyl fumarate (DMF) is an orally administered disease‐modifying drug used for the treatment of multiple sclerosis (MS) in numerous countries worldwide. Aim An ongoing post‐marketing surveillance (PMS) is assessing the real‐world safety and effectiveness of DMF in Japanese patients with MS.
Hirofumi Ochi   +15 more
wiley   +1 more source

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