John Cunningham (JC) Virus Encephalitis Without Progressive Multifocal Leukoencephalopathy in a Stem Cell Transplant Patient: A Case Report and Literature Review. [PDF]
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Distinguishing Progressive Multifocal Leukoencephalopathy From Cerebral Toxoplasmosis in HIV: A Case Report. [PDF]
Wai HHH +4 more
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Ethical and Clinical Considerations in the Workup of HIV-Associated Neurocognitive Decline. [PDF]
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Cortical lesions are common in a longitudinal progressive multifocal leukoencephalopathy cohort. [PDF]
Walvekar S +10 more
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The emergence of progressive multifocal leukoencephalopathy (PML) in rheumatic diseases
Journal of Autoimmunity, 2008Progressive multifocal leukoencephalopathy (PML) is a rare and devastating neurological disease with areas of demyelination in the central nervous system classically associated with profound imunosuppression. PML is caused by reactivation of latent JC virus, leading to the death of myelin-producing oligodendrocytes typically with a rapidly fatal ...
Aftab Ahmed Ansari
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Progressive Multifocal Leukoencephalopathy (PML)
2014Progressive multifocal leukoencephalopathy (PML) was first considered a distinct neurological entity in 1958. Its neuropathology is represented by multifocal demyelinating lesions accompanying oligodendroglia-like cells with markedly enlarged nuclei. Electron microscopy in 1965 showed polyomavirus-like structures in the enlarged nuclei.
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Spontaneous progressive multifocal leukoencephalopathy (PML) in macaques
Nature, 1975PROGRESSIVE multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) which has so far been recognised only in man1,2. Although it is an infrequent cause of clinical neurological disorder3, it is of particular interest because of its frequent association with diseases in which immunological competence is ...
D H, Gribble +3 more
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Are astrocytes infected in progressive multifocal leukoencephalopathy (PML)?
Acta Neuropathologica, 1982Ultrastructural characteristics of the early steps of PML virus infection, i.e. adsorption, penetration, and intracellular virus transport were demonstrated in astrocytes. These phenomena were more frequently seen in the cytoplasm than virus assembly in the nuclei. Infection of the astrocytes is usually non-productive.
M, Mázló, I, Tariska
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