Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.Abstract Aim In individuals with cognitive decline, depressive symptoms can affect disease progression and quality of life. One factor that may be associated with depressive symptoms is phosphorylated tau (p‐tau). However, the association between p‐tau and depressive symptoms remains controversial.
Takashi Ozaki +7 more
wiley +1 more source
Progressive Supranuclear Palsy Syndrome: An Overview
IBRO Neuroscience ReportsProgressive supranuclear palsy (PSP) is a neurodegenerative disease, commonly observed as a movement disorder in the group of parkinsonian diseases. The term PSP usually refers to PSP-Richardson’s syndrome (PSP-RS), the most typical clinical presentation.
Eduardo Ichikawa-Escamilla +2 more
doaj +1 more source
Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders. [PDF]
, 2019 Purpose of reviewThe aim of this study was to examine the synaptic biomarker neurogranin in cerebrospinal fluid (CSF) in different stages of HIV infection and in relation to what is known about CSF neurogranin in other neurodegenerative diseases.Recent ...
Blennow, Kaj +6 more
core +1 more source
Neuronal network disintegration: common pathways linking neurodegenerative diseases [PDF]
, 2016 Neurodegeneration refers to a heterogeneous group of brain disorders that progressively evolve. It has been increasingly appreciated that many neurodegenerative conditions overlap at multiple levels and therefore traditional clinicopathological ...
Ahmed, RM +10 more
core +2 more sources
Progressive supranuclear palsy as the sole manifestation of systemic Whipple's disease treated with pefloxacine. [PDF]
, 1991 Pierre Amarenco +3 more
openalex +1 more source
Atypical Frontotemporal Dementia Associated With SQSTM1 Gene Mutation: A Clinicopathological Case
Neuropathology, Volume 45, Issue 6, December 2025.ABSTRACT A 78‐year‐old man presented with a six‐year history of progressive memory decline, initially manifesting as recent memory impairment and mild anomia, which gradually evolved into motor clumsiness, gait disturbances, language difficulties, behavioral changes, and late‐onset parkinsonism. He had been diagnosed with Paget disease of bone (PDB) at
Christian Espinoza‐Vinces +8 more
wiley +1 more source
The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration. [PDF]
, 2018 Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated.
Lansdall, CJ, Passamonti, L, Rowe, JB
core +1 more source
Cancer, Volume 131, Issue 21, 1 November 2025.Proteolysis‐targeting chimeras use the ubiquitin (Ub)–proteasome system to selectively break down oncogenic proteins, including previously undruggable targets. By providing long‐lasting suppression with lower toxicity, they are becoming a revolutionary approach for personalized cancer treatment.
Yamile Abuchard Anaya +7 more
wiley +1 more source
Natural history of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) and clinical predictors of survival: a clinicopathological study. [PDF]
, 1996 Irene Litvan +8 more
openalex +1 more source
Complement dysregulation in human tauopathies
Brain Pathology, Volume 35, Issue 6, November 2025.Complement protein and activation product levels were assessed in post‐mortem frontal cortex from three distinct subtypes of Tauopathy: Corticobasal degeneration, globular glial tauopathy, and Pick's disease. Quantification of complement proteins by immunohistochemistry and ELISA showed elevation of key complement proteins (C1q) regulators (FI) and ...
Jacqui Nimmo +3 more
wiley +1 more source