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Progressive supranuclear palsy: progression and survival
Journal of Neurology, 2015Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder characterized by postural instability and falls, vertical supranuclear gaze palsy, parkinsonism with poor levodopa response, pseudobulbar palsy, and frontal release signs. The natural history of the disease has been previously described.
Arena, Julieta E +7 more
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Caregiving in progressive supranuclear palsy
Neurology, 1998Basic issues regarding factors influencing progressive supranuclear palsy (PSP) patient caregiver burden remain unresolved, including whether and how disease severity and duration influence caregiver burden.To examine the relation between PSP patient caregiver burden and disease severity, describe the time course of caregiver burden in relation to ...
Jordan Grafman +3 more
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The Epidemiology of Progressive Supranuclear Palsy
2008Publisher Summary This chapter describes that the incidence of progressive supranuclear palsy (PSP) is approximately 1 per 100,000 and the prevalence is approximately 5 per 100,000. Most patients ascertained by such community-based surveys were not previously diagnosed as having PSP, testament to the low sensitivity to the diagnosis on the part of ...
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Progressive Supranuclear Palsy
Archives of Neurology, 1995In 1964, Steele, Richardson, and Olszewski defined a predominantly supranuclear multisystem degenerative disorder that has become known as progressive supranuclear palsy (PSP). Considered rare, although not so, the disorder has been, and continues to be, misdiagnosed.
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The neuropathology of progressive supranuclear palsy
1994The macroscopical, histological, ultrastructural and immunocytochemical features of progressive supranuclear palsy (PSP) are reviewed. Recent investigations have revealed important differences in the distribution, ultrastructure and immunocytochemical profile of neurofibrillary tangles in PSP and in Alzheimer's disease.
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Update on progressive supranuclear palsy
Current Neurology and Neuroscience Reports, 2004A better understanding of the challenges in the diagnosis of progressive supranuclear palsy (PSP), the most common atypical parkinsonian neurodegenerative disorder, has led to improving its diagnostic accuracy. Similarly, a better understanding of the role of tau mutations, mitochondrial complex I inhibitors, oxidative injury, and inflammation in ...
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Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies
Nature Reviews Neurology, 2021Maria Stamelou +2 more
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Mutations disrupting neuritogenesis genes confer risk for cerebral palsy
Nature Genetics, 2020Sheng Chih Jin, Sara A Lewis, Xue Zeng
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