Results 71 to 80 of about 22,412 (293)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Progressivity comparisons [PDF]
Analysts should correct for distributional differences before undertaking local progressivity comparisons between income tax or tax and benefit schedules.
Peter J. Lambert, Valentino Dardoni
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Differential Mortality by Income and Social Security Progressivity [PDF]
There is a widespread belief that people with low lifetime labor income have higher age specific mortality and lower remaining life expectancies at age 60 or 65 than those with middle or high lifetime earnings.
Gopi Shah Goda, John Shoven, Sita Slavov
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
RetosThe study aims to compare the experience of implementing a progressive taxation system in the EU countries with the taxation system in Central Asia to establish the prospects for reforms in this area.
Azamat Baimagambetov, Serik Omirbayev
doaj +1 more source
Are There Opportunities to Increase Social Security Progressivity Despite Underfunding? [PDF]
, 2008 Reviews the payroll tax, Social Security's benefit formula, and outcomes by race, gender, and earnings level, and explores why low-income and minority groups do not receive greater returns on contributions.
Gordon B. T. Mermin +1 more
core +2 more sources
Beyond aspect: will be -ing and shall be -ing [PDF]
, 2010 This article discusses the synchronic status and diachronic development of will be -ing and shall be -ing (as in I’ll be leaving at noon).2 Although available since at least Middle English, the constructions did not establish a significant foothold in ...
Adamczewski +55 more
core +3 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source