Results 181 to 190 of about 7,232 (211)

Prohibitin and the senescent phenotype

Experimental Gerontology, 1996
Prohibitin is an evolutionarily conserved gene that has antiproliferative activity, is ubiquitously expressed, and appears to be essential for cell survival. The gene codes for a 30 kD, post-synthetically modified protein located primarily in the mitochondria.
R T, Dell'Orco, J K, McClung, E R, Jupe, X T, Liu   +3 more
openaire   +2 more sources

Identification and characterization of prohibitin as a receptor protein mediating DENV-2 entry into insect cells

Virology, 2010
Dengue is transmitted primarily by mosquitoes of the Aedes genus. Despite a number of studies, no insect dengue virus receptor protein has been clearly identified and characterized.
Atichat Kuadkitkan, Duncan R Smith
exaly   +2 more sources

Molecular modeling of prohibitin domains

Proteins: Structure, Function, and Bioinformatics, 2007
AbstractProhibitins comprise a family of highly conserved ubiquitous eukaryotic proteins that mainly localize to the mitochondria. They have been implicated in important cellular processes such as cellular signaling and transcriptional control, apoptosis, cellular senescence, and mitochondrial biogenesis.
Winter, Anja, Kamarainen, Outi, Hofmann, Andreas   +2 more
openaire   +3 more sources

Prohibitin in Adipose and Immune Functions

Trends in Endocrinology & Metabolism, 2016
Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence.
Sudharsana R, Ande, K Hoa, Nguyen, B L Grégoire, Nyomba, Suresh, Mishra   +3 more
openaire   +2 more sources

Prohibitin deficiency blocks proliferation and induces apoptosis in human hepatoma cells: Molecular mechanisms and functional implications

Proteomics, 2010
Prohibitin is a multifunctional protein participating in a plethora of essential cellular functions, such as cell signaling, apoptosis, survival and proliferation.
Enrique Santamariá, VÍCTOR Segura, Jesus Prieto   +2 more
exaly   +2 more sources

Identification of prohibitin as an antigen in Behcet’s disease

Biochemical and Biophysical Research Communications, 2014
This study is intended to screen potential antigen for Behcet's disease (BD) by using human microvascular endothelial cells (HUVEC).Following cell-based indirect immunofluorescence assay with sera from BD patients, proteins extracted from HUVEC were separated and detected by Western blotting.
Yiping, Xun, Peng, Chen, Hai, Yan, Weikang, Yang, Lili, Shi, Guangyu, Chen, Hongwu, Du   +6 more
openaire   +2 more sources

Prohibitin plays a role in the functional plasticity of macrophages

Molecular Immunology, 2022
Immunometabolism plays a crucial role in the activation and functional plasticity of immune cells, which in large determines a variety of health and disease states. Factors that integrate immunometabolism in immune cell signaling and functions are beginning to be identified.
Yang Xin Zi, Xu, Sudharsana Rao, Ande, Nnamdi M, Ikeogu, Kecheng, Zhou, Jude E, Uzonna, Suresh, Mishra   +5 more
openaire   +2 more sources

Prohibitin: a potential target for new therapeutics

Trends in Molecular Medicine, 2005
Prohibitin (PHB) is localized to the mitochondria where it might have a role in the maintenance of mitochondrial function and protection against senescence. There is considerable controversy concerning the function of nuclear-localized PHB. PHB has potential roles as a tumor suppressor, an anti-proliferative protein, a regulator of cell-cycle ...
Suresh, Mishra, Leigh C, Murphy, B L Gregoire, Nyomba, Liam J, Murphy   +3 more
openaire   +2 more sources

Prohibitin Signaling at the Kidney Filtration Barrier

2017
The kidney filtration barrier consists of three well-defined anatomic layers comprising a fenestrated endothelium, the glomerular basement membrane (GBM) and glomerular epithelial cells, the podocytes. Podocytes are post-mitotic and terminally differentiated cells with primary and secondary processes.
Christina, Ising, Paul T, Brinkkoetter
openaire   +2 more sources

Emerging roles of prohibitins in cancer: an update

Cancer Gene Therapy
The prohibitin (PHB) family, including PHB1 and its homolog PHB2, is ubiquitously located in different cellular compartments and plays roles in fundamental cellular processes such as proliferation, differentiation, and apoptosis. Accumulating evidence has indicated that this family contributes to the development of numerous diseases in particular ...
Yunliang Gao, Yuanyuan Tang
openaire   +2 more sources