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Approaching Inflammation Paradoxes—Proinflammatory Cytokine Blockages Induce Inflammatory Regulators
Frontiers in Immunology, 2020 The mechanisms that underlie various inflammation paradoxes, metabolically healthy obesity, and increased inflammations after inflammatory cytokine blockades and deficiencies remain poorly determined.
Jason Saredy, Ruijing Zhang, Ying Shao
exaly +4 more sources
Frontiers in Immunology, 2020 Macrophages are professional phagocytes that are uniquely situated between the innate and adaptive arms of immunity with a high capacity for phagocytosis and proinflammatory cytokine production as well as antigen presentation.
Durga Acharya +3 more
doaj +2 more sources
Granzymes Regulate Proinflammatory Cytokine Responses [PDF]
The Journal of Immunology, 2015 Abstract Granzymes (Grs) are serine proteases mainly produced by cytotoxic lymphocytes and are traditionally considered to cause apoptosis in tumor cells and virally infected cells. However, the cytotoxicity of several Grs is currently being debated, and additional, predominantly extracellular, functions of Grs in inflammation are ...
A. Wensink, C. Hack, N. Bovenschen
semanticscholar +5 more sources
PROCALCITONIN AND PROINFLAMMATORY CYTOKINE INTERACTIONS IN SEPSIS
Shock, 1999 Immunoneutralization of procalcitonin (ProCT), a putative mediator of sepsis, has been shown to increase survival in an animal model of sepsis. To better understand the role that ProCT plays in the sepsis cascade, we studied the relationship of this hormone to the proximal proinflammatory mediators, IL-1beta and TNFalpha. Hamsters were made septic by i.
Keven T. Whang +6 more
openalex +5 more sources
Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients [PDF]
International Journal of Dentistry, 2023 Diabetes mellitus has been regarded as a condition capable of influencing the evolution of periapical lesions. Therefore, this study evaluated the immunoexpression of IL-1β, TNF-α, and IL-17 in apical periodontitis from type 2 diabetic patients through ...
Estéfano Borgo Sarmento +9 more
doaj +2 more sources
High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes [PDF]
Journal of Experimental Medicine, 2000 Lipopolysaccharide (LPS) is lethal to animals because it activates cytokine release, causing septic shock and tissue injury. Early proinflammatory cytokines (e.g., tumor necrosis factor [TNF] and interleukin [IL]-1) released within the first few hours of
Jan Andersson +10 more
openalex +2 more sources
Frontiers in Immunology, 2019 It is known that Trypanosoma congolense infection in mice is associated with increased production of proinflammatory cytokines by macrophages and monocytes.
Chukwunonso Onyilagha, Jude E Uzonna
exaly +3 more sources
Proinflammatory and anti-inflammatory cytokine changes related to menopause
Menopause Review, 2014 The aim of the study was to determine menopause-related changes in serum levels of main proinflammatory and anti-inflammatory cytokines. Material and methods: The study included 175 women, who were divided into 5 study groups (group 1 – fertile ...
Andrei Mihai Malutan +3 more
doaj +2 more sources
Rheumatoid arthritis and the proinflammatory cytokine IL-17 [PDF]
Folia Medica, 2023 Introduction: Rheumatoid arthritis (RA) is the most common inflammatory joint disease. Various proinflammatory cytokines are involved in the pathogenesis of this chronic disorder.
Pavel Selimov +8 more
doaj +3 more sources
Frontiers in Cellular and Infection Microbiology, 2022 AimSmoker COPD patients with chest radiological signs of prior tuberculosis (TB) showed more severe lung damage, but the mechanisms remain unclear. Emerging evidence has implicated NK cells in the pathogenesis of both COPD and TB.
Yafei Rao +8 more
doaj +1 more source