Results 91 to 100 of about 1,021,035 (396)
Journal of Biomedical Science, 2009 Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial apoptosis- and proinflammatory cytokine ...
Lee Hsuan-Shu +7 more
doaj +1 more source
In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA‐approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK cell cytotoxicity, investigate if immune cell
Benjamin J. Murdock +8 more
wiley +1 more source
Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models. [PDF]
PLoS ONE, 2013 The p38 MAPK pathway plays a key role in regulating the production of proinflammatory cytokines, such as TNFα and IL-1β, in peripheral inflammatory disorders.
Bin Xing +2 more
doaj +1 more source
The Inflammatory Response in Human Keratinocytes Exposed to Cinnamaldehyde Is Regulated by Nrf2
Antioxidants, 2022 Keratinocytes (KC) play a crucial role in epidermal barrier function, notably through their metabolic activity and the detection of danger signals. Chemical sensitizers are known to activate the transcription factor nuclear factor (erythroid-derived 2 ...
Romain Vallion +7 more
doaj +1 more source
Journal of Biological Chemistry, 2014 Background: Low molecular mass hyaluronan (LMHA) is proinflammatory, but the role of the N-acetyl moieties is unknown. Results: Chemical reacetylation of LMHA results in maximal proinflammatory cytokine production by human macrophages, compared with ...
O. Babasola +4 more
semanticscholar +1 more source
Metabolic Consequences of Rheumatoid Arthritis
Arthritis Care &Research, EarlyView.Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry +2 more
wiley +1 more source
Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. [PDF]
, 2014 Complex interactions between the immune system and the brain might have important aetiological and therapeutic implications for neuropsychiatric brain disorders.
Cousins, Lesley +5 more
core +2 more sources
VHH-Based Bispecific Antibodies Targeting Cytokine Production
Frontiers in Immunology, 2017 Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions, their ...
Maxim A. Nosenko +18 more
doaj +1 more source
Anti‐inflammatory activity of arctigenin against PCV2 infection in a mouse model
Veterinary Medicine and Science, 2022 Arctigenin (ACT) is a novel anti‐inflammatory lignan extracted from Arctium lappa L, a herb commonly used in traditional Chinese herbal medicine.
Lijun Wu +7 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective This study investigated whether sleep disturbance can predict the extent to which pain interferes with daily functioning in patients with early rheumatoid arthritis (RA). Methods Data were from adults with early RA (joint symptoms ≤12 months) enrolled in the Canadian Early Arthritis Cohort between 2016 and 2023.
Burcu Aydemir +16 more
wiley +1 more source