Results 11 to 20 of about 1,021,035 (396)

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

Scientific Reports, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19) that emerged in human populations recently. Severely ill COVID-19 patients exhibit the elevation of proinflammatory cytokines, and
Chia-Ming Su, Leyi Wang, D. Yoo
semanticscholar   +1 more source

Expression of MicroRNA 146a, 155, 181 and 223 in febrile seizure

The Turkish Journal of Pediatrics, 2021
Background. We studied microRNAs (miRNAs) -146a, -155, -181 and -223 expressions and proinflammatory cytokine levels in children with Febrile seizure (FS) and compared to febrile controls. Methods.
Kürşat Bora Çarman, Yasemin Karal, Gülen Gül Mert, Arzu Ekici, Peren Perk, Didem Arslantaş, Coskun Yarar, Ener Çağrı Dinleyici   +7 more
doaj   +1 more source

Treadmill Running Improves Spatial Learning Memory Through Inactivation of Nuclear Factor Kappa B/Mitogen-Activated Protein Kinase Signaling Pathway in Amyloid-β-Induced Alzheimer Disease Rats [PDF]

International Neurourology Journal, 2021
Purpose Exercise is known to reduce proinflammatory cytokines production and apoptosis. We investigated the effect of treadmill running on spatial learning memory in terms of activation of nuclear factor kappa B (NF-κB) and mitogen-activated protein ...
Sang-Hoon Kim, Young Jun Ko, Jee-Youn Kim, Young-Je Sim   +3 more
doaj   +1 more source

Nuclear RPSA senses viral nucleic acids to promote the innate inflammatory response

Nature Communications, 2023
Innate sensors initiate the production of type I interferons (IFN-I) and proinflammatory cytokines to protect host from viral infection. Several innate nuclear sensors that mainly induce IFN-I production have been identified.
Yan Jiang, Siqi Sun, Yuan Quan, Xin Wang, Yuling You, Xiao Zhang, Yue Zhang, Yin Liu, Bingjing Wang, Henan Xu, Xuetao Cao   +10 more
doaj   +1 more source

Glycyrrhizin Inhibits PEDV Infection and Proinflammatory Cytokine Secretion via the HMGB1/TLR4-MAPK p38 Pathway

International Journal of Molecular Sciences, 2020
Our previous study showed that glycyrrhizin (GLY) inhibited porcine epidemic diarrhea virus (PEDV) infection, but the mechanisms of GLY anti-PEDV action remain unclear.
Ruyi Gao, Yongshuai Zhang, Yuhui Kang, Weiyin Xu, Luyao Jiang, Tingting Guo, Changchao Huan   +6 more
semanticscholar   +1 more source

Association of Common Polymorphisms in the Interleukin-1 Beta Gene with Hepatocellular Carcinoma in Caucasian Patients with Chronic Hepatitis B

Pathogens, 2022
Interleukin-1 beta (IL-1β) promotes liver disease progression and hepatocarcinogenesis in chronic hepatitis B (CHB). Single nucleotide polymorphisms (SNPs) within the promotor region of the IL-1β gene can affect the progression towards liver cirrhosis ...
Janett Fischer, Shuang Long, Eleni Koukoulioti, Tobias Müller, Balazs Fueloep, Renate Heyne, Mohammed Eslam, Jacob George, Fabian Finkelmeier, Oliver Waidmann, Thomas Berg, Florian van Bömmel   +11 more
doaj   +1 more source

PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip

Frontiers in Immunology, 2022
Pleckstrin homology-like domain, family A, member 1 (PHLDA1) has been reported to be expressed in many mammalian tissues and cells. However, the functions and exact mechanisms of PHLDA1 remain unclear.
Hui Peng, Hui Peng, Juping Wang, Xuhong Song, Jiangni Huang, Haoming Hua, Fanlu Wang, Ziyun Xu, Jing Ma, Jie Gao, Jing Zhao, Anna Nong, Dongyang Huang, Bin Liang   +13 more
doaj   +1 more source

Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. [PDF]

, 2015
Parasitic helminth infections can be associated with lifelong morbidity such as immune-mediated organ failure. A better understanding of the host immune response to helminths could provide new avenues to promote parasite clearance and/or alleviate ...
A Tarkowski, AL Moncayo, AM Gan, B Min, Cathy Steel, CH Kuo, CM Steppan, D Artis, D Voehringer, DD Taub, DR Herbert, DR Herbert, DR Neill, Edward J. Pearce, F Chen, Gang Chen, GD Thomas, Graham Le Gros, H Helmby, HK Park, HS Jung, J Bethony, J Urban, J Wang, JA Jackson, Jessica C. Jang, JF Urban Jr, JI Odegaard, JJ Reece, Josiah I. Chung, JT Pesce, K Migita, KT Cuenco, L Boring, L Le Goff, L Patel, LC Osborne, M Lehrke, M Lehrke, M Qatanani, Mali Camberis, Mark A. Barnes, Meera G. Nair, MG Nair, MG Nair, MG Nair, Mitchell A. Lazar, MM Pirvulescu, MP Reilly, N Silswal, P Loke, PF Weller, Philip J. Cooper, PJ George, PJ Hotez, R Anuradha, RM Anthony, RT Semnani, RZ Yang, S Babu, S Babu, S Babu, S Babu, S Jiang, S Lee, Spencer H. Wang, Thomas B. Nutman, TT MacDonald, W He, Y Benomar, YY Hsieh   +70 more
core   +9 more sources

Cytokine Signature in Schnitzler Syndrome: Proinflammatory Cytokine Production Associated to Th Suppression

Frontiers in Immunology, 2020
BackgroundSchnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever and monoclonal IgM gammopathy.
Marie Masson Regnault, Marie Masson Regnault, Eric Frouin, Eric Frouin, Isabelle Jéru, Adriana Delwail, Sandrine Charreau, Sébastien Barbarot, Antoine Néel, Antoine Néel, Agathe Masseau, Xavier Puéchal, Xavier Kyndt, Stephane Gayet, François Lifermann, Bouchra Asli, Xavier Balguerie, Claire Blanchard-Delaunay, François Aubin, Rita Rizzi, Franco Rongioletti, Thierry Boyé, Laurence Gusdorf, Didier Bessis, Franck Morel, Ewa Hainaut, Ewa Hainaut, Dan Lipsker, Jean-Claude Lecron, Jean-Claude Lecron   +29 more
doaj   +1 more source

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Journal of Clinical Investigation, 1998
Apoptosis in vivo is followed almost inevitably by rapid uptake into adjacent phagocytic cells, a critical process in tissue remodeling, regulation of the immune response, or resolution of inflammation.
V. Fadok, D. Bratton, A. Konowal, Peter W. Freed, J. Westcott, P. Henson   +5 more
semanticscholar   +1 more source