Results 291 to 300 of about 1,021,035 (396)

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

open access: yesAdvanced Science, EarlyView.
The MOF material UIO‐66‐NH2 is functionalized with DBCO groups on its surface, encapsulating NO‐prednisolone and conjugating it with azide‐modified IL‐10. Finally, the complex is extruded with MM to form biomimetic functional nanoparticles. Upon intra‐articular injection, MI@UN, enveloped by the MM, specifically targets synovial macrophages, is ...
Wenwei Li   +10 more
wiley   +1 more source

Cleavage of protein kinase c δ by caspase-3 mediates proinflammatory cytokine-induced apoptosis in pancreatic islets. [PDF]

open access: yesJ Biol Chem
Collins J   +5 more
europepmc   +1 more source

Covalent Organic Frameworks‐Delivered Reuterin Drives Trained Immunity in Tumor‐Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism

open access: yesAdvanced Science, EarlyView.
Covalent organic framework (COF)‐reuterin induces trained immunity in tumor‐associated macrophages, promoting the generation of nitric oxide and reactive oxygen species, thereby enhancing the antitumor immune response. Additionally, COF‐Reuterin directly kills tumor cells while simultaneously eradicating pathogenic intratumoural bacteria.
Jian‐Gang Zhang   +8 more
wiley   +1 more source

HMOS 2'FL and 3FL prevent house dust mite induced proinflammatory cytokine release <i>in vitro</i> and decrease specific IgE production in a murine allergic asthma model. [PDF]

open access: yesFront Nutr
Zuurveld M   +10 more
europepmc   +1 more source

The Proinflammatory Cytokines in Children with Autism

open access: yesPakistan Journal of Biological Sciences, 2006
Amany Salah El Din El Wakkad   +1 more
openaire   +2 more sources

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate

open access: yesAdvanced Science, EarlyView.
ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen   +17 more
wiley   +1 more source

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