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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.

Annual Review of Immunology, 1995
Interleukin-12 (IL-12) is a heterodimeric cytokine produced mostly by phagocytic cells in response to bacteria, bacterial products, and intracellular parasites, and to some degree by B lymphocytes.
G. Trinchieri
semanticscholar   +1 more source

Proinflammatory cytokines in acute asthma

The Lancet, 1991
Cytokine-mediated interactions between monocytes/macrophages, lymphocytes, and eosinophils may be important in regulation of airway inflammation in asthma. Peripheral blood cytokine concentrations were measured in twenty adults with severe, acute asthma, ten with mild asthma (intermittent inhaled beta-agonists), twelve with chronic asthma (high-dose ...
P.H. Brown   +2 more
openaire   +3 more sources

Proinflammatory cytokines in allergic rhinitis

European Archives of Oto-Rhino-Laryngology, 1995
Allergic diseases such as allergen-induced rhinitis represent an inflammatory reaction that is characterized by the chemotaxis and activation of various cell populations. A high degree of cell-to-cell communication is needed to orchestrate this inflammatory immune response. A variety of cytokines and adhesion receptors seem to play an important role in
U. Ganzer   +4 more
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Extracellular HMGB1 as a Proinflammatory Cytokine

Journal of Interferon & Cytokine Research, 2004
High mobility group box-1 protein (HMGB1, formerly known as HMG-1), a highly conserved ubiquitous protein, has been for a long time described as a nuclear DNA-binding protein involved in nucleosome stabilization and gene transcription. Recent discoveries indicate that HMGB1 is released from activated innate immune cells or necrotic cells and functions ...
Haichao Wang   +3 more
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Proinflammatory Cytokines in Heart Disease

Blood Purification, 2001
Proinflammatory cytokines affect nearly all tissues and organ systems, and the vasculature is no exception. Although a considerable amount of research has focused on the role of the two most prominent proinflammatory cytokines, interleukin-1 (IL-1) and tumor necrosis factor (TNF), in the pathogenesis of sepsis and septic shock, the role of these and ...
Pomerantz Benjamin, Charles A. Dinarello
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Morphogen and proinflammatory cytokine release kinetics from PRGF-Endoret fibrin scaffolds: evaluation of the effect of leukocyte inclusion.

Journal of Biomedical Materials Research. Part A, 2015
The potential influence of leukocyte incorporation in the kinetic release of growth factors from platelet-rich plasma (PRP) may explain the conflicting efficiency of leukocyte platelet-rich plasma (L-PRP) scaffolds in tissue regeneration.
E. Anitua   +4 more
semanticscholar   +1 more source

Proinflammatory cytokine and cancer

American Journal of BioMedicine, 2016
Many investigators have suggested that different cytokines may be important players in the development and progression of cancer and tumor biology. Cytokines are integral to many different aspects of cancer, including development/advancement, treatment, and prognosis. However, so far most cytokine -based therapy trials have fallen short of expectations.
Song Zheng, Wu Wang
openaire   +1 more source

Proinflammatory cytokines in cardiac myxomas

Journal of Internal Medicine, 1992
Serum levels of various cytokines were measured in three patients with cardiac myxomas presenting with and without constitutional symptoms, immunological features and elevated plasma levels of interleukin‐6. Interleukin‐6 but not other cytokines (interleukin‐1, tumour necrosis factor‐α, interferon‐γ) relate to immunological features of the patients ...
Norbert Reinisch   +5 more
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Proinflammatory cytokines and osteoporosis

Current Osteoporosis Reports, 2009
Experimental studies indicate that the proinflammatory cytokines interleukin-1, interleukin-6, and tumor necrosis factor-alpha are important regulators of bone resorption and may play an important role in age- and estrogen deficiency-related bone loss.
openaire   +3 more sources

Proinflammatory Cytokines

Chest, 2000
To review the concept of proinflammatory cytokines.Review of published literature.Academic (university hospital).Cytokines are regulators of host responses to infection, immune responses, inflammation, and trauma. Some cytokines act to make disease worse (proinflammatory), whereas others serve to reduce inflammation and promote healing (anti ...
openaire   +3 more sources

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