Results 351 to 360 of about 1,021,035 (396)
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Antibodies to proinflammatory cytokines
2000Tumour necrosis factor-alpha (TNF-α) is a key molecule in T-helper-1 (Th1) type mucosal inflammation. Results of studies demonstrate variable increases in TNF-α production in the mucosa of patients with active Crohn’s disease (CD) but not ulcerative colitis (UC).
S. R. Targan, L. C. Karp
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Properties of the novel proinflammatory supergene "intercrine" cytokine family.
Annual Review of Immunology, 1991A family consisting of at least ten distinct novel 8-10 kd cytokines has been identified over the past 12 years. These cytokines exhibit from 20 to 45% homology in amino acid sequence, are probably all basic heparin-binding polypeptides, and have ...
J. Oppenheim +3 more
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Indian Journal of Medical Microbiology, 2022
Cytokines are important immune-modulators and improper T-cell activation can lead to cytokine storms which are believed to result in endothelial permeability and leakage, a typical feature of Dengue disease progressing into a more severe stage. Many cytokines have been implied in causing severe Dengue manifestations among which IL-10 poses to be an ...
Saishruti, Iyer, G, Sucila Thangam
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Cytokines are important immune-modulators and improper T-cell activation can lead to cytokine storms which are believed to result in endothelial permeability and leakage, a typical feature of Dengue disease progressing into a more severe stage. Many cytokines have been implied in causing severe Dengue manifestations among which IL-10 poses to be an ...
Saishruti, Iyer, G, Sucila Thangam
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Dynamic Regulation of Proinflammatory Cytokines
1999Proinflammatory cytokines, including interleukin-1beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α), are proteins created and released by a wide variety of immune cells in response to infection, inflammation, and tissue damage. These proteins have long been recognized as critical communication factors for orchestrating early responses of ...
Kien T. Nguyen +3 more
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Leptin as a Proinflammatory Cytokine
2006Leptin is a 16-kDa protein produced mainly by adipocytes. Animal models demonstrate that leptin is required for control of bodyweight and reproduction, since mice defective in leptin or the leptin receptor are obese, hyperphagic insulin resistant and infertile.
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Proinflammatory Cytokines and Treatment of Disease
Annals of the New York Academy of Sciences, 1998ABSTRACT: Bacterial infections in the immunocompromised host cause considerable mortality, and even recently developed antimicrobial strategies often fail to cure these infections, especially in granulocytopenic patients. Cytokines and hematopoietic growth factors have been shown to stimulate host defense mechanisms in vitro and in vivo.
Meer, J.W.M. van der +3 more
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Regulation of autoimmunity by proinflammatory cytokines
Current Opinion in Immunology, 1998Studies extending over a decade have provided compelling evidence to suggest that chronic expression of proinflammatory cytokines in vivo leads to unique regulatory properties that target the cognate immune response in a way that appears to be beneficial to the host.
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Proinflammatory cytokines, microRNAs and schizophrenia
Journal of Neuroimmunology, 2014Epstein–Barr virus (EBV) has been identified as a putative trigger of multiple sclerosis (MS). We hypothesized that latent EBV infection alters the immune response to a second stimulus thereby exacerbating autoimmunity. Previously, we reported that mice latently infected with murine gamma herpesvirus 68 (gammaHV-68), the murine homolog to EBV, were ...
Anil K. Malhotra +3 more
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Proinflammatory Plasma Cytokines in Children With Migraine
Pediatric Neurology, 2009Toward understanding the role of cytokines in migraine, this study focused on selected proinflammatory cytokines. The study group consisted of 21 children who had migraine with and without aura; the control group was 24 children with episodic tension-type headache.
Leszek Boćkowski +2 more
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Proinflammatory cytokines in hypersensitivity pneumonitis.
American Journal of Respiratory and Critical Care Medicine, 1995We examined the synthesis and release of the proinflammatory cytokines macrophage inflammatory protein-1 alpha (MIP-1 alpha) and interleukin-8 (IL-8) in the context of subjects with hypersensitivity pneumonitis (HP). Subjects with acute HP were found to have alveolar macrophages that released high levels of MIP-1 alpha and IL-8, whereas control ...
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