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Proinflammatory Chemical Signaling: Cytokines [PDF]

, 2014
An increasing body of data has documented altered cytokine concentrations from Parkinson’s disease brains and its rodent models. These changes have been reported in the periphery as well as in the cerebrospinal fluid, where they may be released from a variety of cell types to possibly traffic to and from the brain.
Kumi Nagamoto-Combs, Colin K. Combs
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Tomoregulin ectodomain shedding by proinflammatory cytokines

Life Sciences, 2003
The shedding mechanism for the tomoregulin (TR) ectodomain, which contains two follistatin modules and a single epidermal growth factor (EGF)-like domain, remains unclear. Our study provides the first evidence that proinflammatory cytokines, IL-1beta and TNF-alpha, induce TR-ectodomain shedding in cultured A172 human glioma cells, without affecting TR ...
Hong Lin, Tomonori Akamatsu, Ken Wada, Choitsu Sakamoto, Taku Tsukui, Kei Shinoki, Masaoki Yonezawa   +6 more
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HMGB1, a potent proinflammatory cytokine in sepsis

Cytokine, 2010
High-mobility group box 1 (HMGB1), a highly conserved protein previously known as a DNA-binding protein involved in maintenance of nucleosome structure and regulation of gene transcription, was recently found to act as a potent proinflammatory cytokine during infection responses.
Yaoqing Tang, Lei Li, Wenchang Huang
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Regulation of Neutrophil Functions by Proinflammatory Cytokines

International Journal of Hematology, 2006
Various functions of mature human neutrophils are activated or potentiated by hematopoietic growth factors or proinflammatory cytokines such as granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor alpha, and interleukin 1beta.
Takayuki Kato, Seiichi Kitagawa
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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

Nature Reviews Rheumatology, 2010
Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane, although the etiology and pathogenesis underlying this debilitating disease are poorly understood. Secreted inflammatory molecules, such as proinflammatory cytokines, are among the critical mediators of the disturbed ...
Jean-Pierre Pelletier, Johanne Martel-Pelletier, Hassan Fahmi, Mohit Kapoor, Daniel Lajeunesse   +4 more
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Proinflammatory cytokines in cervicogenic headache.

Functional neurology, 1999
Interleukin-1 beta (IL-1 beta) and Tumour Necrosis Factor-alpha (TNF-alpha) exert their multifunctional biological effect by promoting and increasing the molecular events of cellular inflammation. The aim of this study was to find out whether the cytokine pattern of cervicogenic headache (CH) patients tends, like that seen in cluster headache, towards ...
MARTELLETTI, Paolo, G. Stirparo, M. Giacovazzo   +2 more
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Role of Proinflammatory Cytokines in Acetaminophen Hepatotoxicity

Toxicology and Applied Pharmacology, 1995
Acetaminophen (APAP) intoxication has been shown to activate Kupffer cells. Kupffer cell activation is also associated with the release of proinflammatory cytokines which can induce a variety of pathophysiological responses. These studies examined whether proinflammatory cytokines are produced in response to a hepatotoxic dose of APAP, and if so, the ...
S.D. Holladay, Mark E. Blazka, Ralph E. Wilson, J.L. Wilmer, Michael I. Luster   +4 more
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Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment.

Oral Diseases, 2012
OBJECTIVE The aim of this study was to evaluate the effects of periodontal treatment on serum and gingival crevicular fluid (GCF) proinflammatory cytokine levels in hyperlipidemic patients with periodontitis.
Ö. Fentoğlu, F. Kırzıoğlu, M. Özdem, H. Kocak, R. Sutcu, T. Sert   +5 more
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Effect of proinflammatory cytokines on PIGA− hematopoiesis

Experimental Hematology, 2003
Blood cells from patients with paroxysmal nocturnal hemoglobinuria lack glycosyl phosphatidylinositol (GPI)-linked proteins, due to a somatic mutation in the X-linked PIGA gene. It is believed that clonal expansion of PIGA- blood cells is due to a survival advantage in the hostile marrow environment of aplastic anemia.
Monica Bessler, Shashikant Kulkarni
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Proinflammatory cytokines in intestinal mucosa [PDF]

Immunologic Research, 1991
A. Voss, A. Raedler, I. Pfluger, J. Petersen, M. Steffen, Hans Christian Reinecker, C. Doehn   +6 more
openaire   +2 more sources