Results 31 to 40 of about 1,021,035 (396)
Frontiers in Aging Neuroscience, 2021 The sulfonylurea drug gliquidone is FDA approved for the treatment of type 2 diabetes. Binding of gliquidone to ATP-sensitive potassium channels (SUR1, Kir6 subunit) in pancreatic β-cells increases insulin release to regulate blood glucose levels ...
Jieun Kim +7 more
doaj +1 more source
Proinflammatory Cytokine Gene Polymorphisms in Bullous Pemphigoid
Frontiers in Immunology, 2019 Bullous pemphigoid (BP) is a rare autoimmune skin blistering disease, characterized by the presence of autoantibodies against hemidesmosomal autoantigens. Cytokine expression is altered in BP patients, and several of these differently expressed cytokines,
Pardis-Sadat Tabatabaei-Panah +13 more
doaj +1 more source
Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression
Cell Death and Disease, 2018 Necroptosis, a form of regulated necrotic cell death, is mediated by receptor interacting protein 1 (RIPK1), RIPK3, and mixed lineage kinase domain-like protein (MLKL).
Kezhou Zhu +9 more
semanticscholar +1 more source
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core +1 more source
Proinflammatory Cytokines and Periodontal Disease [PDF]
Journal of Dental Problems and Solutions, 2016 Review Numerous biological procedures are strictly controlled by cell-cell interactions, which are categorized into two forms: cognate (adhesive) interactions, attained by mutual recognition between membrane-bound cell-surface molecules; and cytokine-mediated interactions [1].
openaire +3 more sources
Btp Proteins from Brucella abortus Modulate the Lung Innate Immune Response to Infection by the Respiratory Route [PDF]
, 2017 Although inhalation of infected aerosols is a frequent route for Brucella infection in humans, it rarely causes pulmonary clinical manifestations, suggesting a mild or nearly absent local inflammatory response.
Baldi, Pablo Cesar +6 more
core +1 more source
Cancer Research, 2016 STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations.
S. Koyama +33 more
semanticscholar +1 more source
Proinflammatory Cytokines and Potassium Channels in the Kidney [PDF]
Mediators of Inflammation, 2015 Proinflammatory cytokines affect several cell functions via receptor‐mediated processes. In the kidney, functions of transporters and ion channels along the nephron are also affected by some cytokines. Among these, alteration of activity of potassium ion (K+) channels induces changes in transepithelial transport of solutes and water in the kidney ...
Manabu Kubokawa +2 more
openaire +3 more sources
The Crohn’s Disease and Proinflammatory Cytokines [PDF]
, 2021 Abstract The aim of the study was to examine the profile of the main proinflammatory cytokines in the serum of patients with Crohn's disease and establish their association with the severity and activity of the disease. A total of 61 patients (29 women (47.5%), 32 men (52.5%) aged from 18 to 40 years (mean age (30.42 ± 2.51) years) with the ...
Kiril Kirov +2 more
openaire +2 more sources
Altered expression of cytokines in mice infected intranasally with two syncytial variants of Herpes simplex virus type 1 [PDF]
, 2014 Immune evasion strategies are important for the onset and the maintenance of viral infections. Many viruses have evolved mechanisms to counteract or suppress the host immune response.
Adler +31 more
core +2 more sources